Fluorination strategies are important in assisting the synthesis of pharmaceuticals. Iodine(I/III) catalysis has become particularly useful for installing gem-difluoro groups but is limited to styrenes. Now, the hypervalent iodane-catalysed difluorination of enynes has enabled access to diverse homopropargylic difluorides.
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Epplin, R.C., Gulder, T. Enyne difluorination. Nat. Chem. 15, 1484–1485 (2023). https://doi.org/10.1038/s41557-023-01352-5
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DOI: https://doi.org/10.1038/s41557-023-01352-5
