Tandem cycloaddition reactions have significant applications in organic synthetic chemistry. Now, two enzymes are shown to catalyse tandem hetero-Diels–Alder reactions with a synergistic interplay between a calcium cofactor and N-glycan post-translational modifications during the biosynthesis of bistropolone-sesquiterpene secondary metabolites.
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Ushimaru, R., Abe, I. Back-to-back cycloadditions in nature. Nat. Chem. 15, 1056–1057 (2023). https://doi.org/10.1038/s41557-023-01282-2
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DOI: https://doi.org/10.1038/s41557-023-01282-2
