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Nucleic acid-based sensors

Selecting aptamers with programmed affinities

Constructing aptamers with desired target-binding affinities may lead to new applications but is challenging. Now, a new method using a high-dimensional microfluidic approach enables quantitative isolation of aptamers with programable binding affinities.

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Fig. 1: Pro-SELEX enables the selection of aptamers with different binding affinities.

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Correspondence to Ping Song or Chunhai Fan.

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Song, P., Fan, C. Selecting aptamers with programmed affinities. Nat. Chem. 15, 747–748 (2023). https://doi.org/10.1038/s41557-023-01215-z

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