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Selective cycloadditions

2+2-cycloaddition reactions have long been considered key transformations in the biosynthesis of cyclobutane-containing natural products, but enzymes for these reactions have not yet been identified. Now, a 2+2 cyclase has been discovered, characterized and bioengineered to catalyse cycloadditions with different selectivity.

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Fig. 1: Discovery of an enzymatic 2+2 cycloaddition.


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Correspondence to Hui Ming Ge.

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Zhang, B., Ge, H.M. Selective cycloadditions. Nat. Chem. 15, 167–169 (2023).

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