2+2-cycloaddition reactions have long been considered key transformations in the biosynthesis of cyclobutane-containing natural products, but enzymes for these reactions have not yet been identified. Now, a 2+2 cyclase has been discovered, characterized and bioengineered to catalyse cycloadditions with different selectivity.
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Zhang, B., Ge, H.M. Selective cycloadditions. Nat. Chem. 15, 167–169 (2023). https://doi.org/10.1038/s41557-022-01123-8