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MOLECULAR CAPSULES

Hopping protons in supramolecular catalysis

Supramolecular catalysis can emulate many features of enzymatic transformations. Now, a complex proton wire mechanism — enabling the dual activation of a nucleophile and an electrophile through reciprocal proton transfer — has been shown to operate during the β-glycosylation of sugars within a self-assembled capsule.

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Fig. 1: Proton wire activation mode and substrate scope.

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Correspondence to Cally J. E. Haynes or Larissa K. S. von Krbek.

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Haynes, C.J.E., von Krbek, L.K.S. Hopping protons in supramolecular catalysis. Nat. Chem. 14, 969–971 (2022). https://doi.org/10.1038/s41557-022-01024-w

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