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SYNTHETIC METHODOLOGY

Radical ring formation

N-heterocycles are valuable motifs in pharmaceuticals and materials, but divergent synthetic strategies are lacking. Now, bifunctional sulfilimines have been shown to form nitrogen-centred radicals under photocatalytic conditions, and subsequent coupling with olefins enables the synthesis of diverse N-heterocycles.

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Fig. 1: Discovery of a bifunctional reagent for N-heterocycle synthesis.

References

  1. Richter, M. F. et al. Nature 545, 299–304 (2017).

    CAS  Article  Google Scholar 

  2. Vitaku, E., Smith, D. T. & Njardarson, J. T. J. Med. Chem. 57, 10257–10274 (2014).

    CAS  Article  Google Scholar 

  3. Lovering, F., Bikker, J. & Humblet, C. J. Med. Chem. 52, 6752–6756 (2009).

    CAS  Article  Google Scholar 

  4. Cheng, Q., Bai, Z., Tewari, S. & Ritter, T. Nat. Chem. https://doi.org/10.1038/s41557-022-00997-y (2022).

    Article  PubMed  Google Scholar 

  5. Berger, F. & Ritter, T. Synlett 33, 339–345 (2022).

    CAS  Article  Google Scholar 

  6. Vo, C.-V. T., Mikutis, G. & Bode, J. W. Angew. Chem. Int. Ed. 52, 1705–1708 (2013).

    CAS  Article  Google Scholar 

  7. Yar, M., McGarringle, E. M. & Aggarwal, V. K. Angew. Chem. Int. Ed. 47, 3784–3786 (2008).

    CAS  Article  Google Scholar 

  8. Holst, D. E., Wang, D. J., Kim, M., Guzei, I. A. & Wickens, Z. K. Nature 596, 74–79 (2021).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Wei Li.

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Baskaran, P., Li, W. Radical ring formation. Nat. Chem. 14, 850–852 (2022). https://doi.org/10.1038/s41557-022-01006-y

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