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Hydration determines anion accumulation

Why do bulky anions solubilize macromolecules in water but precipitate out the corresponding monomers? The answer lies in the differences in local water structure. Polymers have now been shown to disrupt water structure more than their monomers, leading to an accumulation of anions near the polymers that increases their solubility.

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Fig. 1: Solute hydration determines the accumulation of weakly hydrated anions and their influence on solubility.


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Correspondence to Amish J. Patel.

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Thosar, A.U., Patel, A.J. Hydration determines anion accumulation. Nat. Chem. 14, 8–10 (2022).

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