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Tying peptide ropes

Although the natural lasso peptide microcin J25 remains an elusive target for total chemical synthesis itself, this topologically non-trivial building block has now been used to construct a range of interlocked molecular architectures including rotaxanes, catenanes and daisy chains.

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Fig. 1: A lasso peptide and its conversion into other structures.


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Correspondence to Jan H. van Maarseveen.

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van Maarseveen, J.H. Tying peptide ropes. Nat. Chem. 13, 822–823 (2021).

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