Nucleic acids can adopt G-quadruplex folds whose cellular roles remain poorly defined. Synthesis of new probes has now enabled the identification of human proteins that interact with G-quadruplexes. This could provide new clues to decipher the function of these curious folds.
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Fleming, A.M., Burrows, C.J. Deciphering nucleic acid knots. Nat. Chem. 13, 618–619 (2021). https://doi.org/10.1038/s41557-021-00739-6
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DOI: https://doi.org/10.1038/s41557-021-00739-6
