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NUCLEIC ACIDS

Designing in vivo active DNAzymes

The therapeutic applications of DNAzymes are limited because of their low effectiveness in vivo. Now, a promising approach for constructing DNAzymes that show high gene-silencing efficiency in mammalian cells has been developed. This approach incorporates chemical modifications into an existing DNAzyme scaffold.

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Fig. 1: Design of DNAzymes for efficient gene silencing in vivo.

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Correspondence to Chuanzheng Zhou.

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Zhou, Y., Zhou, C. Designing in vivo active DNAzymes. Nat. Chem. 13, 299–301 (2021). https://doi.org/10.1038/s41557-021-00669-3

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  • DOI: https://doi.org/10.1038/s41557-021-00669-3

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