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PHOTOCHEMISTRY

A light touch for complex products

The [2+2] photocycloaddition of two double-bond moieties is arguably the most efficient way to form a four-membered ring, but this route is rarely used to construct azetidine rings. Now, the development of an isoxazoline carboxylate cycloaddition partner offers a general approach to synthesize diverse azetidine products.

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Fig. 1: The development of a broadly applicable protocol for intermolecular aza-Paternò–Büchi reactions to generate diverse azetidine products.

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Correspondence to Susannah Coote.

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Coote, S. A light touch for complex products. Nat. Chem. 12, 889–890 (2020). https://doi.org/10.1038/s41557-020-0536-y

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