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INTRINSICALLY DISORDERED PROTEINS

Predictable phase-separated proteins

Nature Chemistry volume 12, pages 787–789 (2020)Cite this article

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An approach to design artificial intrinsically disordered proteins using a short peptide as a repeating unit has been reported. This design enables the phase behaviour of the protein to be finely tuned inside cells and enabled the formation of phase-separated condensates that can modulate chemical reactions.

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Fig. 1: Schematic demonstration of the design principle of artificial-IDPs (A-IDPs) for phase separation.

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  1. Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai, India

    Soumik Ray & Samir K. Maji

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  1. Soumik Ray
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  2. Samir K. Maji
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Correspondence to Samir K. Maji.

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The authors declare no competing interests.

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Ray, S., Maji, S.K. Predictable phase-separated proteins. Nat. Chem. 12, 787–789 (2020). https://doi.org/10.1038/s41557-020-0532-2

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