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Exploring epigenetics with chemical tools

Identifying chromatin modifications and their interactomes is imperative to understand how chromatin functions and is regulated. Now, two new studies report on chemical tools that enable characterization of the biological interactions within native chromatin.

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Fig. 1: In nucleo semi-synthesis of the modified histone protein and its incorporation in chromatin.
Fig. 2: The ChromID approach identifies interactomes of histone PTMs and methylated DNA.


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Correspondence to Tatiana G. Kutateladze.

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Zhang, Y., Kutateladze, T.G. Exploring epigenetics with chemical tools. Nat. Chem. 12, 506–508 (2020).

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