Interfacing electronic and genetic circuits

Synthetic genetic circuits leverage the information processing capability of biological machinery to tackle complex sensing tasks, yet they lack many of the advantages inherent to electrical computation. Now, an interface has been designed that provides an electrical output for synthetic genetic circuits.

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Fig. 1: Illustration of the electrochemical interface for gene-circuit-based sensors.


  1. 1.

    Sedlmayer, F., Aubel, D. & Fussenegger, M. Nat. Biomed. Eng. 2, 399–415 (2018).

  2. 2.

    Slusarczyk, A. L., Lin, A. & Weiss, R. Nat. Rev. Genet. 13, 406–420 (2012).

  3. 3.

    Hodgman, C. E. & Jewett, M. C. Metab. Eng. 14, 261–269 (2012).

  4. 4.

    Sadat Mousavi, P. et al. Nat. Chem. (2019).

  5. 5.

    Green, A. A., Silver, P. A., Collins, J. J. & Yin, P. Cell 159, 925–939 (2014).

  6. 6.

    Labib, M., Sargent, E. H. & Kelley, S. O. Chem. Rev. 116, 9001–9090 (2016).

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Correspondence to Robbyn K. Anand.

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Anand, R.K., Rahn, K.L. Interfacing electronic and genetic circuits. Nat. Chem. 12, 14–16 (2020).

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