The structure of an antibiotic that is effective against Gram-positive bacteria, but not against Gram-negative bacteria, has now been modified to improve its effectiveness against Gram-negative bacteria. The approach could help broaden the spectrum of activity of other antibiotics.
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Fisher, J.F., Mobashery, S. A positive positive to negative. Nature Chem 10, 998–1000 (2018). https://doi.org/10.1038/s41557-018-0148-y
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DOI: https://doi.org/10.1038/s41557-018-0148-y