News & Views | Published:


SNAr stands corrected

Dynamic covalent chemistry combines the error-correcting behaviour of supramolecular chemistry with the robustness of covalent bonding, but relies on a somewhat limited set of reactions. Now, the classic nucleophilic aromatic substitution (SNAr) reaction has been shown to be reversible and self-correcting.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Zhang, W. & Jin, Y. Dynamic Covalent Chemistry: Principles, Reactions, and Applications. (Wiley-VCH, Weinheim, 2017).

  2. 2.

    Rowan, S. J., Cantrill, S. J., Cousins, G. R. L., Sanders, J. K. M. & Stoddart, J. F. Angew. Chem. Int. Ed. 41, 898–952 (2002).

  3. 3.

    Jin, Y., Yu, C., Denman, R. J. & Zhang, W. Chem. Soc. Rev. 42, 6634–6654 (2013).

  4. 4.

    Corbett, P. T. et al. Chem. Rev. 106, 3652–3711 (2006).

  5. 5.

    Ong, W. J. & Swager, T. M. Nat. Chem. (2018).

  6. 6.

    Zhang, W. & Moore, J. S. Angew. Chem. Int. Ed. 45, 4416–4439 (2006).

Download references

Author information

Correspondence to Wei Zhang.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: Dynamic, self-correcting SNAr reaction.
Fig. 2: Macrocycle and polymer synthesized through SNAr.