An ultrahigh-energy neutrino event detected with the IceCube detector in Antarctica, simultaneous and co-spatial with a multi-wavelength outburst of a blazar about 3 billion light years away, points unambiguously to lepto-hadronic cooling mechanisms in jetted active galactic nuclei.
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Pian, E. Cosmic hadron colliders. Nat Astron 3, 24–25 (2019). https://doi.org/10.1038/s41550-018-0613-y