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Erratum: Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

npj Aging and Mechanisms of Diseasevolume 3, Article number: 10 (2017) | Download Citation

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Erratum to: npj Aging and Mechanisms of Disease (2017); doi:10.1038/s41514-017-0005-z; Published 15 August 2017

After online publication of this article, the authors noticed an error in Fig. 2.

Fig. 2
Fig. 2

Overexpression of dPrp19 leads to dose-dependent extension of female but not male life span. Effects of the induction of the dPrp19 UAS cassette in three independent chromosomal insertions of the same transgenic construct on adult survival and dPrp19 mRNA levels: a, b TubGS-Gal4 > UAS-dPrp19-1 (females only), c–f daGS-Gal4 > UAS-dPrp19-2(females and males), and g–j daGS-Gal4 > UAS-dPrp19-4 (females and males). a, c, e, g, and i show survival curves of experimental flies at three concentrations of the inducer drug RU486; b, d, f, h, and j show quantification of dPrp19 expression levels relative to the Rp49 control after 72 h of exposure to 300 µg/ml RU486. For all three overexpression constructs, we find a significant dose-dependent extension of female life span. Overall, we did not find any life span extension in males (for daGS-Gal4 > UAS-dPrp19-2 males at 100 µg/ml RU486 we observed a slight reduction in survival, possibly due to inadvertent ‘‘setup mortality” that might have occurred when the assay was set-up). For details of life span statistics see Supplementary Table 1 (females) and Supplementary Table 2 (males); for experimental details see Materials and Methods

In panels a, c, and g of Fig. 2, there are the y-axes missing. The correct version of this figure appears below as Fig. 2.

This has now been corrected in the HTML and PDF versions of this Article.

The authors apologize for any inconvenience caused.

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The online version of the original article can be found at http://dx.doi.org/10.1038/s41514-017-0005-z.

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Affiliations

  1. Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland

    • Kathrin Garschall
    •  & Thomas Flatt
  2. Department of Biotechnology, BOKU – University of Natural Resources and Life Sciences, Vienna, Vienna, Austria

    • Hanna Dellago
    • , Markus Schosserer
    •  & Johannes Grillari
  3. Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria

    • Martina Gáliková
    •  & Thomas Flatt
  4. Department of Developmental Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

    • Martina Gáliková
  5. Christian Doppler Laboratory on Biotechnology of Skin Aging, Dept. of Biotechnology, BOKU – University of Natural Resources and Life Sciences, Vienna, Vienna, Austria

    • Johannes Grillari
  6. Evercyte GmbH, Vienna, Austria

    • Johannes Grillari

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Correspondence to Markus Schosserer or Thomas Flatt.

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DOI

https://doi.org/10.1038/s41514-017-0008-9