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The cell surface is the place to be for brassinosteroid perception and responses

Nature Plants volume 10, pages 206–218 (2024)Cite this article

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Abstract

Adjusting the microenvironment around the cell surface is critical to responding to external cues or endogenous signals and to maintaining cell activities. In plant cells, the plasma membrane is covered by the cell wall and scaffolded with cytoskeletal networks, which altogether compose the cell surface. It has long been known that these structures mutually interact, but the mechanisms that integrate the whole system are still obscure. Here we spotlight the brassinosteroid (BR) plant hormone receptor BRASSINOSTEROID INSENSITIVE1 (BRI1) since it represents an outstanding model for understanding cell surface signalling and regulation. We summarize how BRI1 activity and dynamics are controlled by plasma membrane components and their associated factors to fine-tune signalling. The downstream signals, in turn, manipulate cell surface structures by transcriptional and post-translational mechanisms. Moreover, the changes in these architectures impact BR signalling, resulting in a feedback loop formation. This Review discusses how BRI1 and BR signalling function as central hubs to integrate cell surface regulation.

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Fig. 1: BRI1 levels and activity controls at the PM.
Fig. 2: Cell surface regulation by the BR pathway in A. thaliana seedling development.
Fig. 3: BR controls the feedback loop coupled by several mechanisms.

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Acknowledgements

We apologize to authors whose work is related to BR-driven cell surface regulation but could not be cited because of either our oversight or space limitation. We thank S. Moussu for the critical reading of the manuscript. This work was supported by a PhD fellowship from the University Toulouse 3-Paul Sabatier to C.D., research grants from Agence Nationale de la Recherche (ANR-17-CE20-0026-01 to G.V. and ANR-22-CE13-0021-01 to S.F.) and the French Laboratory of Excellence (project ‘TULIP’ grant nos ANR-10-LABX-41 and ANR-11-IDEX-0002-02 to G.V.).

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  1. Plant Science Research Laboratory (LRSV), UMR5546 CNRS/Université Toulouse 3, Auzeville-Tolosane, France

    Charlotte Delesalle, Grégory Vert & Satoshi Fujita

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  1. Charlotte Delesalle
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C.D., G.V. and S.F. conceptualized the structure of the paper. C.D. wrote the original draft of the paper. C.D., G.V. and S.F. reviewed and edited the manuscript. C.D. and S.F. produced the figures. S.F. and G.V. supervised the manuscript.

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Correspondence to Satoshi Fujita.

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Delesalle, C., Vert, G. & Fujita, S. The cell surface is the place to be for brassinosteroid perception and responses. Nat. Plants 10, 206–218 (2024). https://doi.org/10.1038/s41477-024-01621-2

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