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Molecular engineering

The power of repetition

The inclusion of retrotransposon long terminal repeats — and of other repeated sequences — enhances transfer DNA copy numbers in plant cells during transformation. Gene editing and homologous recombination-mediated gene targeting can therefore be improved by these means: however, the mechanism remains a mystery.

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Fig. 1: An alternative model for repeat-induced DNA amplification.

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Correspondence to Holger Puchta.

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Puchta, H. The power of repetition. Nat. Plants 9, 1377–1378 (2023). https://doi.org/10.1038/s41477-023-01496-9

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