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Plant promoter-proximal pausing?

A study of a synthetic auxin response circuit in a heterologous system suggests that hindrance of Mediator complex function by the co-repressor TOPLESS may represent a form of promoter pausing, a mechanism that has not been described in plants before.

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Fig. 1: Models of promoter pausing in metazoans and plants.

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Correspondence to Nicholas Morffy or Lucia C. Strader.

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Morffy, N., Strader, L.C. Plant promoter-proximal pausing?. Nat. Plants 7, 862–863 (2021). https://doi.org/10.1038/s41477-021-00970-6

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