Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Sp(l)icing up PepR signalling

Alternative splicing provides a fundamental and ubiquitous mechanism of gene regulation. Stimuli-induced retention of introns introduces novel proteoforms with altered signalling output: full-length CPK28 blocks immune signalling, while a truncated variant, lacking calcium responsiveness, promotes it.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: PepR-induced alternative splicing overrides post-translational modification (PTM)-controlled immune suppression to allow response amplification.


  1. Ross, A. et al. EMBO J. 33, 62–75 (2014).

    Article  CAS  Google Scholar 

  2. Hander, T. et al. Science 363, eaar7486 (2019).

  3. Wang, J. et al. Mol. Cell 69, 493–504 (2018).

    Article  CAS  Google Scholar 

  4. Monaghan, J. et al. Cell Host Microbe 16, 605–615 (2014).

    Article  CAS  Google Scholar 

  5. Dressano, K. et al. Nat. Plants (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ding, F. et al. BMC Genomics 15, 431 (2014).

    Article  Google Scholar 

  7. Hake, K. & Romeis, T. Plant Cell Environ. 42, 904–917 (2019).

    Article  CAS  Google Scholar 

  8. Bazin, J. et al. PLoS Pathog. 16, e1008401 (2020).

    Article  CAS  Google Scholar 

  9. Bender, K. W. et al. J. Biol. Chem. 292, 3988–4002 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Lennart Wirthmueller or Tina Romeis.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wirthmueller, L., Romeis, T. Sp(l)icing up PepR signalling. Nat. Plants 6, 912–913 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing