Alternative splicing provides a fundamental and ubiquitous mechanism of gene regulation. Stimuli-induced retention of introns introduces novel proteoforms with altered signalling output: full-length CPK28 blocks immune signalling, while a truncated variant, lacking calcium responsiveness, promotes it.
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Wirthmueller, L., Romeis, T. Sp(l)icing up PepR signalling. Nat. Plants 6, 912–913 (2020). https://doi.org/10.1038/s41477-020-0708-1
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DOI: https://doi.org/10.1038/s41477-020-0708-1