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BASE EDITING

Off-target effects and the solution

Adenine base editors (ABEs) and cytosine base editors (CBEs) are powerful tools for targeted base conversions, but their editing specificities are largely unknown. Now, two reports demonstrate that ABEs are highly specific, but BE3-type CBEs tend to generate genome-wide off-target single nucleotide variations.

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Correspondence to Yao-Guang Liu.

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Fig. 1: Targeting specificity of base editors.