Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR–Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.
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This work was supported by a grant from Institute for Basic Science (IBS-R021-D1).
J.-S.K. is a co-founder of and holds stock in ToolGen, Inc. focused on genome editing.
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Kim, JS. Precision genome engineering through adenine and cytosine base editing. Nature Plants 4, 148–151 (2018). https://doi.org/10.1038/s41477-018-0115-z
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