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Raising the BAR of specificity


Phosphinothricin resistance is a widely used trait in plant science research and agriculture. The BAR resistance gene that inactivates phosphinothricin has now been shown to produce two non-specific metabolites in planta. An engineered BAR resistance gene with no detectable off-target activity is developed to address this issue.

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Fig. 1: Activity of BAR and engineered BAR enzyme.


  1. 1.

    Hoerlein, G. Rev. Environ. Contam. Toxicol. 138, 73–145 (1994).

    CAS  PubMed  Google Scholar 

  2. 2.

    Malcolm D. & Preston, C. in Herbicides and The ir Mechanisms of Action (eds Cobb, A. H. & Kirkwood, R. C.) 72–104 (CRC, Sheffield, 2000).

  3. 3.

    Botterman, J. & Leemans, J. Prospects for Amino Acid Biosynthesis Inhibitors in Crop Protection and Pharmaceutical Chemistry 63–68 (Monograph 42, BCPC, 1989).

  4. 4.

    Christ, B. et al. Nat. Plants (2017).

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Correspondence to Sarah E. O’Connor.

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The author declares no competing financial interests.

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O’Connor, S.E. Raising the BAR of specificity. Nature Plants 3, 924–925 (2017).

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