Abstract
POIS is a rare condition characterized by multisystem symptoms with unclear aetiology. Various attempts have been made to characterize this condition and knowledge is still evolving regarding its aetiology and effective treatment. We have summarized the findings in the English language literature for this rare condition. PubMed search was performed and over 300 English language articles which were screened for relevance. 34 articles were deemed suitable for inclusion. POIS occurs in age range of 21–61 years. Onset of symptoms is usually within 45 min and lasts for an average of 7 days. Primary POIS accounts for approximately half of the cases in literature. The three commonest symptoms were fatigue (68.7), poor concentration (63.9%) and irritation (51.9%). Treatments with variable efficacy which have been proposed include hyposensitisation, antihistamines, alpha blockers, NSAIDS and testosterone replacements. POIS is an important condition which affects the quality of life of men. It is vital that it is managed on a sound scientific basis
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 8 print issues and online access
$259.00 per year
only $32.38 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Data availability
Data from the research is available within the article and can be provided on request from the authors(BO, IP).
References
Waldinger MD, Schweitzer DH. Postorgasmic Illness Syndrome: Two Cases. J Sex Marital Ther. 2002;28:251–5.
Jiang N, Xi G, Li H, Yin J. Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE-Mediated Allergy to Semen. J Sex Med. 2015;12:840–5.
Takeshima T, Kuroda S, Yumura Y. Case of post‐orgasmic illness syndrome associated with hypogonadism. IJU Case Rep. 2020;3:189–91.
Kawamura H, Watanabe T, Yamamura H, Sano S, Kanaoka M, Watanabe Y, et al. Post-orgasmic illness syndrome with positive intradermal test for autologous semen. J Dermatol. 2023;50:951–5.
Hamdi G, Ben Ammar H, Charaa O, Brahmi L, Maamri A, Zalila H. The first Tunisian case of postorgasmic illness syndrome: A case report. Clin Case Rep. 2021; https://doi.org/10.1002/ccr3.5120.
De Amicis K, Costa PR, Figo DD, De Lima CMF, Castro FFM, Kalil J, et al. Immunophenotypical characterization of a Brazilian POIS (Post-Orgasmic Illness Syndrome) patient: adding more pieces to puzzle. J Sex Marital Ther. 2020;46:227–33.
Su H, Lu Y, Ma C, Li H. Post-orgasmic illness syndrome accompanied with testosterone deficiency: a case report. J Mens Health 2022;18:130.
Depreux N, Basagaña M, Pascal M. Síndrome de enfermedad post-orgásmica: no evidencia de causalidad alérgica. Rev Int Androl. 2018;16:42–44.
Waldinger MD, Meinardi MM, Zwinderman AH, Schweitzer DH. Postorgasmic Illness Syndrome (POIS) in 45 Dutch Caucasian Males: clinical characteristics and evidence for an immunogenic pathogenesis (Part 1). J Sex Med. 2011;8:1164–70.
Reisman Y. Clinical experience with Post-orgasmic illness syndrome (POIS) patients—characteristics and possible treatment modality. Int J Impot Res. 2021;33:556–62.
Ashby J, Goldmeier D. Postorgasm Illness Syndrome - a spectrum of illnesses. J Sex Med. 2010;7:1976–81.
Strashny A. First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS). Int J Impot Res. 2019;31:369–73.
Natale C, Gabrielson A, Tue Nguyen HM, Dick B, Hellstrom WJG. Analysis of the symptomatology, disease course, and treatment of Postorgasmic Illness Syndrome in a large sample. J Sex Med. 2020;17:2229–35.
Bolanos J, Morgentaler A Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin. Urol Case Rep. 2020; https://doi.org/10.1016/j.eucr.2019.101078.
Dexter S. Benign coital headache relieved by partner’s pregnancies with implications for future treatment. Case Rep. 2010;2010:bcr1020092359–bcr1020092359.
Kim TB, Shim YS, Lee SM, Son ES, Shim JW, Lee SP. Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome. Sex Med. 2018;6:174–9.
Waldinger MD. Post orgasmic illness syndrome (POIS). Transl Androl Urol. 2016;5:602–6.
Pierce H, Fainberg J, Gaffney C, Aboukhashaba A, Khan A, Kashanian J. Postorgasmic illness syndrome: potential new treatment options for a rare disorder. Scand J Urol. 2020;54:86–88.
Wrotynska-Barczynska J, Swat E, Berger A, Pawelczyk L, Jedrzejczak P. Intensified Hyposensitization is an effective treatment of Postorgasmic Illness Syndrome (POIS). Sex Med. 2022;10:100474–100474.
Shanholtzer A, Stephens JR, Lauter C, Peters KM. Post orgasmic illness syndrome successfully managed with antihistamine: A case report. Urol Case Rep. 2022; https://doi.org/10.1016/j.eucr.2022.102189.
Padhye M, Trowbridge P, Rubin D. (236) Flibanserin for Post-Orgasmic Illness Syndrome: A Case Report. J Sex Med. 2023; https://doi.org/10.1093/jsxmed/qdad060.222.
McLean-Tooke A, Klinken E. Post-Orgasmic Illness Syndrome successfully treated with Omalizumab: A Case Report. J Sex Marital Ther. 2023;1–4. https://doi.org/10.1080/0092623X.2023.2295256.
Ismail AMA. Complementary role of Benson’s relaxation technique in post orgasmic illness syndrome. The Aging Male. 2023; https://doi.org/10.1080/13685538.2023.2174511.
Huang T-B, Yu J-J, Du Y-J, Liu Z-Y. Novel treatment for post-orgasmic illness syndrome: a case report and literature review. Asian J Androl. 2022;24:332.
Zizzo J, F. Sávio L, Ramasamy R, F. N. Lima T. Postorgasmic Illness Syndrome: An Update. Eur Urol Focus. 2023;9:22–24.
Abdessater M, Elias S, Mikhael E, Alhammadi A, Beley S. Post orgasmic illness syndrome: what do we know till now? Basic Clin Androl. 2019;29:13.
Paulos MR, Avelliino GJ. Post-orgasmic illness syndrome: history and current perspectives. Fertil Steril. 2020;113:13–15.
Nguyen HMT, Bala A, Gabrielson AT, Hellstrom WJG. Post-Orgasmic Illness Syndrome: a review. Sex Med Rev. 2018;6:11–15.
Sonkodi B, Kopa Z, Nyirády P. Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common? Cells. 2021;10:1867.
Serefoglu EC. Post-Orgasmic Illness Syndrome: where are we? J Sex Med. 2017;14:641–2.
Gül M, Fode M, Urkmez A, Capogrosso P, Falcone M, Sarikaya S, et al. A clinical guide to rare male sexual disorders. Nat Rev Urol. 2024;21:35–49.
Orzel J, Rubin R. 042 Successful treatment strategies in two patients with Postorgasmic illness syndrome (POIS). J Sex Med. 2021;18:S23–S24.
Rosetti L, Kanani A, Witherspoon L, Flannigan R, Elliott S. Case series: expanding diagnostic markers in postorgasmic illness syndrome. Sex. Med. 2023; https://doi.org/10.1093/sexmed/qfac021.
Rao TSS, Andrade C. Post-orgasmic Illness Syndrome. J Psychosexual Health. 2023;5:75–76.
Duran MB, Rubin RS, Reisman Y, Serefoglu EC. Recognition and practice patterns of sexual medicine experts towards postorgasmic illness syndrome. Int J Impot Res. 2023; https://doi.org/10.1038/s41443-023-00753-x.
Author information
Authors and Affiliations
Contributions
BO involved in study conception and design, data collection, analysis and manuscript preparation. IP involved in study conception and design, data collection, analysis and manuscript preparation. VB involved in study conception and design, and manuscript preparation.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Odusanya, B.O., Pearce, I. & Modgil, V. Post orgasmic illness syndrome: a review. Int J Impot Res (2024). https://doi.org/10.1038/s41443-024-00860-3
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41443-024-00860-3