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Commentary on: Safety and feasibility of percutaneous needle tunneling with platelet-rich plasma injections for Peyronie’s disease in the outpatient setting: a pilot study

International Journal of Impotence Research volume 36, pages 162–163 (2024)Cite this article

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In the article titled ‘Safety and Feasibility of Percutaneous Needle Tunneling with Platelet-Rich Plasma Injections for Peyronie’s Disease in the Outpatient Setting: A Pilot Study,’ Zugail et al. [1] presented data from a non-randomized, prospective pilot study that investigated the antifibrotic effects of platelet-rich plasma (PRP) injection combined with percutaneous needle tunneling (PNT) and followed by vacuum erection device (VED) application for the treatment of Peyronie’s disease. In this prospective study, 54 patients were enrolled and the main outcome was the improvement in penile curvature. In 87.04% of the patients upon consultation, the curvature of the penis became stable. When they compared the mean curvature angle before (53.98 ± 23.19) and after the use of VED following PNT/PRP (30.09 ± 20.61), they observed a significant improvement (p = 0.001) in the curvature.

The rationale behind this treatment approach is the utilization of injected PRP to modulate fibrosis in Peyronie’s disease. PRP contain various mediators responsible for modulating tissue integrity remodeling, including growth factors, chemotactic molecules, and angiogenic mediators [2].

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References

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Selcuk University School of Medicine, 42250, Konya, Turkey

    Ali Şahin

  2. Department of Urology, Selcuk University School of Medicine, 42250, Konya, Turkey

    Murat Gül

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  1. Ali Şahin
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  2. Murat Gül
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MG and AŞ contributed to the writing and editing of this commentary paper.

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Correspondence to Murat Gül.

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Şahin, A., Gül, M. Commentary on: Safety and feasibility of percutaneous needle tunneling with platelet-rich plasma injections for Peyronie’s disease in the outpatient setting: a pilot study. Int J Impot Res 36, 162–163 (2024). https://doi.org/10.1038/s41443-023-00806-1

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