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Evaluation of sexual functions in female rosacea patients: a prospective, case-control study

International Journal of Impotence Research volume 32, pages 628–634 (2020)Cite this article

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Abstract

Patients with rosacea have a higher incidence of depression, embarrassment, social phobia, stress, subjective disease perception and decreased quality of life. Sexual dysfunction is one of the main factors contributing to impaired life quality. The aim of this study is to evaluate the presence of sexual dysfunction in women with rosacea. A prospective case-control study was planned to investigate female sexual dysfunction in patients utilizing the Female Sexual Function Index (FSFI). A total of 85 patients with rosacea and 80 healthy control subjects were included in the study. The total FSFI scores were significantly lower in the rosacea group than in the control group (26.6 vs. 27.6, p < 0.001, respectively). According to the total FSFI scores, 49.4% of the rosacea patients had sexual dysfunction compared with 30.0% of the healthy controls (p = 0.011). The total FSFI scores were negatively correlated with the values of the Dermatologic Life Quality Index (DLQI) (r: −0.251, p = 0.001), disease duration (r: −0.416, p < 0.001), age (r: −0.632, p < 0.001) and body mass index (r: −0.329, p < 0.001). Sexual dysfunction in female rosacea patients was demonstrated in this study. We believe that the recognition of sexual dysfunction in women with rosacea will provide improvements in the life quality of such patients.

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References

  1. World Health Organization. Defining sexual health: report of a technical consultation on sexual health. Geneva: WHO; 2002.

  2. World Health Organization. Division of Mental Health and Prevention of Substance Abuse. WHOQoL: measuring quality of life. Geneva: World Health Organization; 1997.

  3. Ermertcan AT. Sexual dysfunction in dermatological diseases. J Eur Acad Dermatol Venereol. 2009;23:999–1007.

    Article  CAS  Google Scholar 

  4. Pluchino N, Carmignani A, Cubeddu A, Santoro A, Cela V, Errasti T. Androgen therapy in women: for whom and when. Arch Gynecol Obstet. 2013;288:731–7.

    Article  CAS  Google Scholar 

  5. Kim YH, Kim SM, Kim JJ, Cho IS, Jeon MJ. Does metabolic syndrome impair sexual function in middle- to old-aged women? J Sex Med. 2011;8:1123–30.

    Article  Google Scholar 

  6. Basra MK, Finlay AY. The family impact of skin disease: the Greater Patient concept. Br J Dermatol. 2007;156:929–37.

    Article  CAS  Google Scholar 

  7. Two AM, Wu W, Gallo RL, Hata TR. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors. J Am Acad Dermatol. 2015;72:749–58.

    Article  Google Scholar 

  8. Holmes AD, Spoendlin J, Chien AL, Baldwin H, Chang ALS. Evidence-based update on rosacea comorbidities and their common physiologic pathways. J Am Acad Dermatol. 2018;78:156–66.

    Article  Google Scholar 

  9. Esposito K, Maiorino MI, Bellastella G, Giugliano F, Romano M, Giugliano D. Determinants of female sexual dysfunction in type 2 diabetes. Int J Impot Res. 2010;22:179–84.

    Article  CAS  Google Scholar 

  10. Atlantis E, Sullivan T. Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis. J Sex Med. 2012;9:1497–507.

    Article  Google Scholar 

  11. Kalmbach DA, Kingsberg SA, Ciesla JA. How changes in depression and anxiety symptoms correspond to variations in female sexual response in a nonclinical sample of young women: a daily diary study. J Sex Med. 2014;11:2915–27.

    Article  Google Scholar 

  12. Doumas M, Tsiodras S, Tsakiris A, Douma S, Chounta A, Papadopoulos A, et al. Female sexual dysfunction in essential hypertension: a common problem being uncovered. J Hypertens. 2006;24:2387–92.

    Article  CAS  Google Scholar 

  13. Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, et al. Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002;46:584–7.

    Article  Google Scholar 

  14. Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)–a simple practicalmeasure for routine clinical use. Clin Exp Dermatol. 1994;19:210–6.

    Article  CAS  Google Scholar 

  15. Oztürkcan S, Ermertcan AT, Eser E, Sahin MT. Cross validation of the Turkish version of dermatology life quality index. Int J Dermatol. 2006;45:1300–7.

    Article  Google Scholar 

  16. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female Sexual Function Index (FSFI): a multidimensional selfreport instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26:191–208.

    Article  CAS  Google Scholar 

  17. Aygin D, Aslan FE. The Turkish adaptation of the female sexual function index. Turkiye Klinikleri J Med Sci. 2005;25:393

    Google Scholar 

  18. Cabral PU, Canario AC, Spyrides MH, Uchôa SA, Eleutério J Jr, Gonçalves AK. Determinants of sexual dysfunction among middle-aged women. Int J Gynaecol Obstet. 2013;120:271–4.

    Article  Google Scholar 

  19. Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): Cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005;31:1–20.

    Article  Google Scholar 

  20. Song SH, Jeon H, Kim SW, Paick JS, Son H. The prevalence and risk factors of female sexual dysfunction in young korean women: an internet-based survey. J Sex Med. 2008;5:1694–701.

    Article  Google Scholar 

  21. Duman N, Ersoy Evans S, Atakan N. Rosacea and cardiovascular risk factors: a case control study. J Eur Acad Dermatol Venereol. 2014;28:1165–9.

    Article  CAS  Google Scholar 

  22. Bewley A, Fowler J, Schofer H, Kerrouche N, Rives V. Erythema of rosacea health-related quality of life: results of a meta-analysis. Dermatol Ther. 2016;6:237–47.

    Article  Google Scholar 

  23. Moustafa F, Lewallen RS, Feldman SR. The psychological impact of rosacea and the influence of current management options. J Am Acad Dermatol. 2014;71:973–80.

    Article  Google Scholar 

  24. Bohm D, Schwanitz P, Stock Gissendanner S, Schmid-Ott G, Schulz W. Symptom severity and psychological sequelae in rosacea: results of a survey. Psychol Health Med. 2014;19:586–91.

    Article  Google Scholar 

  25. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA. 1999;281:537–44.

    Article  CAS  Google Scholar 

  26. Laumann EO, Niclsi A, Glasser DB, Paik A, Gingell C, Moreira E, et al. Sexual problems among women and men aged 40–80 years: prevalence and correlates identified in the global study of sexual attitudes and behaviors. Int J Impot Res. 2005;17:39–57.

    Article  CAS  Google Scholar 

  27. Dennerstein L, Alexander JL, Kotz K. The menopause and sexual functioning: a review of the population-based studies. Annu Rev Sex Res. 2003;14:64–82.

    Google Scholar 

  28. Oberg K, Fugl-Meyer AR, Fugl-Meyer KS. On categorization and quantification of women’s sexual dysfunctions: an epidemiological approach. Int J Impot Res. 2004;16:261–9.

    Article  CAS  Google Scholar 

  29. Cayan S, Akbay E, Bozlu M, Canpolat B, Acar D, Ulusoy E. The prevalence of female sexual dysfunction and potential risk factors that may impair sexual function in Turkish women. Urol Int. 2004;72:52–57.

    Article  Google Scholar 

  30. Dunn KM, Croft PR, Hackett GI. Association of sexual problems with social, psychological, and physical problems in men and women: a cross sectional population survey. J Epidemiol Community Health. 1999;53:144–8.

    Article  CAS  Google Scholar 

  31. Hayes RD, Bennett CM, Fairley CK, Dennerstein L. What can prevalence studies tell us about female sexual difficulty and dysfunction? J Sex Med. 2006;3:589–95.

    Article  Google Scholar 

  32. Bachmann G. Female sexuality and sexual dysfunction: are we stuck on the learning curve? J Sex Med. 2006;3:639–45.

    Article  Google Scholar 

  33. Bachmann GA, Leiblum SR. The impact of hormones on menopausal sexuality: a literature review. Menopause. 2004;11:120–30.

    Article  Google Scholar 

  34. Dalpiaz O, Kerschbaumer A, Mitterberger M, Pinggera GM, Colleselli D, Bartsch G, et al. Female sexual dysfunction: a new urogynaecological research field. BJU Int. 2008;101:717–21.

    Article  Google Scholar 

  35. Miner M, Esposito K, Guay A, Montorsi P, Goldstein I. Cardiometabolic risk and female sexual health: the Princeton III summary. J Sex Med. 2012;9:641–51.

    Article  Google Scholar 

  36. Enzlin P, Rosen R, Wiegel M, Brown J, Wessells H, Gatcomb P, et al. Sexual dysfunction in women with type 1 diabetes: long-term findings from the DCCT/EDIC study cohort. Diabetes Care. 2009;32:780–5.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology and Venereology, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey

    Ezgi Aktaş Karabay

  2. Department of Urology, Çukurca State Hospital, Hakkari, Turkey

    Nejdet Karşıyakalı

  3. Department of Urology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey

    Emre Karabay

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  1. Ezgi Aktaş Karabay
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Correspondence to Ezgi Aktaş Karabay.

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Aktaş Karabay, E., Karşıyakalı, N. & Karabay, E. Evaluation of sexual functions in female rosacea patients: a prospective, case-control study. Int J Impot Res 32, 628–634 (2020). https://doi.org/10.1038/s41443-020-0275-z

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