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Comment on “Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study”

International Journal of Impotence Research volume 32, pages 364–365 (2020)Cite this article

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In the article entitled “Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study”, Alahwany et al. [1] presented data from a randomized controlled crossover study that has investigated the effect of hyaluronic acid (HA) injection into the glans penis to treat premature ejaculation (PE). The rationale behind this treatment approach is that the injected HA filler forms a barrier between the skin and the dorsal nerve branches, reducing tactile stimuli. Given that HA is biodegradable, HA injection will not result in permanent sexual dysfunction. The efficacy and safety of HA injection for PE treatment have been confirmed by several studies [2,3,4,5]. However, the findings of those studies cannot be generalized due to their uncontrolled design and their use of nonvalidated questionnaires for assessment.

In this controlled study, 30 patients were randomized to receive either HA or saline injections in their glans penis. After a wash-out period, a crossover assessment and a re-evaluation of both groups were performed. The patients were evaluated based on intravaginal ejaculation latency time (IELT), a validated Arabic index of PE questionnaire and the incidence of adverse events (AEs). The patients who reported improved IELT at the end of the first month were further evaluated at 3, 6, and 9 months intervals by measuring their IELT. Overall, HA injection resulted in PE treatment for up to 9 months by increasing the IELT compared with saline injection.

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References

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Authors and Affiliations

  1. Department of Urology, Aksaray University School of Medicine, Aksaray, Turkey

    Murat Gul

  2. Laboratory of Reproductive Biology, University of Copenhagen, Copenhagen, Denmark

    Murat Gul

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  1. Murat Gul
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Correspondence to Murat Gul.

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Gul, M. Comment on “Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study”. Int J Impot Res 32, 364–365 (2020). https://doi.org/10.1038/s41443-019-0200-5

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  • DOI: https://doi.org/10.1038/s41443-019-0200-5

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