Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Priapism caused by “Rhino 7 Platinum 3000” an over-the-counter male enhancement supplement

Abstract

Male enhancement and erectile dysfunction supplements are typically non-Food and Drug Administration (FDA) approved and readily available for purchase by anyone. Longstanding priapism is a significant potential side effect. A 25-year-old man presented with a 48-h priapism after taking Rhino 7 Platinum 3000. He required bilateral corpo-glanular shunting to alleviate his priapism. On initial 2-week follow-up, he had significant fibrosis of the corporal bodies bilaterally and had been unable to achieve an erection. There are few studies performed and few case reports regarding the roles of various supplements in causing priapism. We are unaware of any studies regarding Rhino 7 Platinum 3000. Interestingly, since our initial contact with the FDA Safety Reporting Portal, multiple investigations of Rhino products have demonstrated that sildenafil is a non-labeled ingredient. Given the lack of FDA oversight of many other supplements similar to this one, patients must be wary that the ingredients listed may not be comprehensive and that serious side effects can occur.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004;9:4–16.

    PubMed  Google Scholar 

  2. Geller AI, et al. Emergency department visits for adverse events related to dietary supplements. N Engl J Med. 2015;373:1531–40. https://doi.org/10.1056/NEJMsa1504267.

    Article  PubMed  CAS  Google Scholar 

  3. Miocinovic R,Zafar S,Sferra J,Wainstein M, Priapism caused by “All Nite Long”. Int J Impot Res. 2005;17:469–70. https://doi.org/10.1038/sj.ijir.3901348.

    Article  PubMed  CAS  Google Scholar 

  4. Coralic Z,Lenhoff T,Kanzaria HK,Gerona R, A 120-hour case of priapism from an over-the-counter herbal supplement. Ann Pharmacother. 2013;47:289–90. https://doi.org/10.1345/aph.1R611.

    Article  PubMed  Google Scholar 

  5. Myers A, Barrueto F Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5:223–5.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Spycher MA, Hauri D. The ultrastructure of the erectile tissue in priapism. J Urol. 1986;135:142–7.

    Article  PubMed  CAS  Google Scholar 

  7. Pryor JP, Hehir M. The management of priapism. Br J Urol. 1982;54:751–4.

    Article  PubMed  CAS  Google Scholar 

  8. Zheng DC, et al. Unsatisfactory outcomes of prolonged ischemic priapism without early surgical shunts: our clinical experience and a review of the literature. Asian J Androl. 2013;15:75–78. https://doi.org/10.1038/aja.2012.63.

    Article  PubMed  CAS  Google Scholar 

  9. Moon HW, et al. Administration of Goji (Lycium chinense Mill.) extracts improves erectile function in old aged rat model. World J Mens Health. 2017;35:43–50. https://doi.org/10.5534/wjmh.2017.35.1.43.

    Article  PubMed  Google Scholar 

  10. Rowland D,Tai W, A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. J Sex Marital Ther. 2003;29:185–205. https://doi.org/10.1080/00926230390155096.

    Article  PubMed  Google Scholar 

  11. Administration, USFD. Public Notification: RHINO 7 Platinum 5000 contains hidden drug ingredient. https://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm234539.htm (2017).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher S. Elliott.

Ethics declarations

Conflict of interest

This event has been submitted to the FDA. The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mittakanti, H.R., Elliott, C.S. Priapism caused by “Rhino 7 Platinum 3000” an over-the-counter male enhancement supplement. Int J Impot Res 30, 190–191 (2018). https://doi.org/10.1038/s41443-018-0033-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41443-018-0033-7

Further reading

Search

Quick links