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Research progress on the application of single-cell sequencing in autoimmune diseases

Genes & Immunity volume 24, pages 220–235 (2023)Cite this article

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Abstract

Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal immune regulation, leading to damage to host organs. The complicated pathogenesis and varied clinical symptoms of AIDs pose great challenges in diagnosing and monitoring this disease. Regrettably, the etiological factors and pathogenesis of AIDs are still not completely understood. It is noteworthy that the development of single-cell RNA sequencing (scRNA-seq) technology provides a new tool for analyzing the transcriptome of AIDs. In this essay, we have summarized the development of scRNA-seq technology, and made a relatively systematic review of the current research progress of scRNA-seq technology in the field of AIDs, providing a reference to preferably understand the pathogenesis, diagnosis, and treatment of AIDs.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (82101877), Central Government Guided Local Science and Technology Development Project (Gui Ke AD20238021), Guilin Science Research and Technology Development Project (20210218-2), Innovation Project of Guangxi Graduate Education (JGY2021140), Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation(2023KF006, 3030302213), and Guangxi Medical and health key cultivation discipline construction project.

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  1. These authors contributed equally: Xueli Yang, Xianliang Hou.

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  1. Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China

    Xueli Yang, Xianliang Hou, Junning Zhang, Zhenyu Liu & Guangyu Wang

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Contributions

HXL, YXL are responsible for conceptualizing and writing the paper; LZY, ZJN, WGY are responsible for collecting and organizing materials; all authors participated in the analysis and discussion of article revisions and approved the final paper.

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Correspondence to Xianliang Hou.

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Yang, X., Hou, X., Zhang, J. et al. Research progress on the application of single-cell sequencing in autoimmune diseases. Genes Immun 24, 220–235 (2023). https://doi.org/10.1038/s41435-023-00216-9

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