Abstract
Objectives
To study the changes in vessel densities (VD) stratified by vessel diameter in the retinal superficial and deep vascular complexes (SVC/DVC) using optical coherence tomography angiography (OCTA) images obtained from people with diabetes and age-matched healthy controls.
Methods
We quantified the VD based on vessel diameter categorized as <10, 10–20 and >20 μm in the SVC/DVC obtained on 3 × 3 mm2 OCTA scans using a deep learning-based segmentation and vascular graph extraction tool in people with diabetes and age-matched healthy controls.
Results
OCTA images obtained from 854 eyes of 854 subjects were divided into 5 groups: healthy controls (n = 555); people with diabetes with no diabetic retinopathy (DR, n = 90), mild and moderate non-proliferative DR (NPDR) (n = 96), severe NPDR (n = 42) and proliferative DR (PDR) (n = 71). Both SVC and DVC showed significant decrease in VD with increasing DR severity (p < 0.001). The largest difference was observed in the <10 μm vessels of the SVC between healthy controls and no DR (13.9% lower in no DR, p < 0.001). Progressive decrease in <10 μm vessels of the SVC and DVC was seen with increasing DR severity (p < 0.001). However, 10–20 μm vessels only showed decline in the DVC, but not the SVC (p < 0.001) and there was no change observed in the >20 μm vessels in either plexus.
Conclusions
Our findings suggest that OCTA is able to demonstrate a distinct vulnerability of the smallest retinal vessels in both plexuses that worsens with increasing severity of DR.
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Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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AEF, MM AMH and SS conceptualized the project. AEF, SB and RRF collected the imaging and patient information. MM, LK, JCP and DR performed the data analysis. AMH performed the statistical analysis. AEF wrote the manuscript. All authors contributed to reviewing the manuscript.
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AF: None, MM: None, LK: None, JCP: None, DR: None, SB: None, AH: Boehringer Ingelheim Ltd (E), SS: Bayer (F), Novartis (F), Abbvie (F), Roche (F), Boehringer Ingelheim (F), Optos (F), EyeBiotech (F), Biogen (F)Apellis (F), Janssen Pharmaceuticals (F), Ocular Therapeutix (F), OcuTerra (F). SS is a member of the Eye Editorial Board.
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Fayed, A.E., Menten, M.J., Kreitner, L. et al. Retinal vasculature of different diameters and plexuses exhibit distinct vulnerability in varying severity of diabetic retinopathy. Eye (2024). https://doi.org/10.1038/s41433-024-03021-4
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DOI: https://doi.org/10.1038/s41433-024-03021-4