Abstract
Purpose
To evaluate the association between dry eye disease (DED) and various psychiatric and systemic diseases in an adult Korean population aged 40 years or older.
Methods
Population-based cross-sectional data of 6,732 participants aged ≥40 years was extracted from the Korea National Health and Nutrition Examination Survey 2017–2018 (KNHANES VII). Data including DED, demographic variables, behavioral factors, psychiatric conditions, and systemic diseases was analysed to determine the prevalence and psychiatric and systemic risk factors for DED.
Results
The weighted prevalence of DED was 7.9 ± 0.4% (mean ± SE). Multivariate analysis showed that female sex and urban residence were associated with an increased risk of DED. The prevalence of DED was lower in patients aged ≥70 years than in those aged 40–69 years. Self-reported psychological conditions including perceived stress and depression were associated with the risk of DED. Self-reported Systemic conditions, such as rheumatoid arthritis, degenerative arthritis, osteoporosis, ischemic heart disease, and chronic renal failure had association with an increased risk of DED.
Conclusion
DED may be associated with several self-reported psychiatric and systemic conditions, which highlights the need for an integrated approach to manage these diseases for optimal treatment of DED.
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Data availability
Data are available from the Korea Center for Chronic Disease and Control Institutional Data Access / Ethics Committee for researchers who meet the criteria for access to confidential data. Data can also be downloaded from the following website: https://knhanes.cdc.go.kr/knhanes/eng/index.do.
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Funding
This paper was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant No. NRF- 2021R1F1A1048448).
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MNL is responsible for design of the study protocol, acquisition and analysis of the data, literature search, and drafting the work. JYL is responsible for design of the study protocol, acquisition and interpretation of the data, literature search, and drafting the work. JYH is responsible for conception of the study protocol, analysis and interpretation of the data, and critical revision of the work. SBH is responsible for conception and design of the study protocol, analysis and interpretation of the data, and critical revision of the work.
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Lim, M.N., Lee, J.Y., Hyon, J.Y. et al. Association of self-reported psychiatric and systemic risk factors in dry eye disease in adult Korean population. Eye 38, 917–922 (2024). https://doi.org/10.1038/s41433-023-02803-6
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DOI: https://doi.org/10.1038/s41433-023-02803-6
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