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  • Review Article
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Amniotic membrane transplantation: structural and biological properties, tissue preparation, application and clinical indications

Eye volume 38, pages 668–679 (2024)Cite this article

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Abstract

The amniotic membrane is a single epithelial layer of the placenta. It has anti-inflammatory, anti-scarring, anti-angiogenic and possibly bactericidal properties. The basement membrane of the amniotic membrane acts as a substrate to encourage healing and re-epithelialisation. It has been used in many ocular surface diseases including persistent epithelial defects (corneal or conjunctival), chemical or thermal burns, limbal stem cell deficiency, cicatrising conjunctivitis, ocular graft versus host disease, microbial keratitis, corneal perforation, bullous keratopathy, dry eye disease, corneal haze following refractive surgery and cross-linking, band keratopathy, ocular surface neoplasia, pterygium surgery, and ligneous conjunctivitis. This review provides an up-to-date overview of amniotic membrane transplantation including the structural and biological properties, preparation and application, clinical indications, and commercially available products.

摘要

羊膜是胎盘的一层单一上皮组织。它具有抗炎、抗瘢痕、抗血管生成和抗菌特性。羊膜的基底膜作为基质, 具有促进愈合和重新上皮化的作用。它用于许多眼表疾病, 包括持续性上皮缺陷(角膜或结膜) 、化学或热烧伤、角膜缘干细胞缺乏、瘢痕性结膜炎、眼部移植物抗宿主疾病、微生物性角膜炎、角膜穿孔、大泡性角膜病变、干眼综合征、屈光矫视和交联术后的角膜混浊、带状角膜病变、眼表肿瘤、翼状胬肉手术和木样结膜炎。本综述提供了羊膜移植的最新概述, 包括结构和生物特性、制备和应用、临床适应症和商用产品。

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Authors and Affiliations

  1. Department of Ophthalmology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK

    Francis W. B. Sanders

  2. Eye and ENT Hospital, Fudan University, Shanghai, China

    Jinhai Huang & Colm McAlinden

  3. Division of Ophthalmology, School of Medicine, Universidad Miguel Hernández, Alicante, Spain; and Cornea, Cataract and Refractive Surgery Department, VISSUM Corporation, Alicante, Spain

    Jorge L. Alió del Barrio

  4. Corneo Plastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead, UK

    Samer Hamada & Colm McAlinden

  5. School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, UK

    Colm McAlinden

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  1. Francis W. B. Sanders
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Manuscript drafting: FWBS, CM. Critical revision: FWBS, JH, JLADB, SH, CM. Final approval: FWBS, JH, JLADB, SH, CM.

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Correspondence to Colm McAlinden.

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Sanders, F.W.B., Huang, J., Alió del Barrio, J.L. et al. Amniotic membrane transplantation: structural and biological properties, tissue preparation, application and clinical indications. Eye 38, 668–679 (2024). https://doi.org/10.1038/s41433-023-02777-5

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