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Factors associated with progressive anisometropia after bilateral intraocular lens implantation in patients with pediatric cataract

Eye volume 38, pages 594–599 (2024)Cite this article

Subjects

Abstract

Objectives

To identify factors associated with progressive anisometropia after bilateral intraocular lens (IOL) implantation in patients with pediatric cataract.

Methods

Clinical and standardized questionnaire data were collected for Sixty-eight patients with pediatric cataract (136 eyes) who underwent bilateral IOL implantation and at least 1 year of follow-up. Univariate and multivariate linear regression models were used to identify factors associated with postoperative anisometropia.

Results

The median age at IOL implantation was 3.2 years (range: 1–12.4 years), and median follow-up time was 5.7 years (range: 1.1–14 years). At 1 month postoperatively and at the last follow-up, there were 19 (27%) and 31 (46%) cases of anisometropia ≥1 D, 9 (13%) and 15 (22%) cases of anisometropia ≥2 D, and 2 (3%) and 9 (13%) cases of anisometropia ≥3 D, respectively. Compared with 1 month postoperatively, the amount of anisometropia increased in 45 (67%) patients. Greater anisometropia one year or more after bilateral IOL implantation was associated with larger intereye difference in IOL power (P = 0.032, 95%CI 0.013 to 0.285), intereye difference in preoperative axial length (P = 0.018, 95%CI –1.247 to –0.123), presence of strabismus (P = 0.017, 95%CI 0.063–0.601), anisometropia at 1 month postoperatively (P = 0.001, 95%CI 0.126–0.478), and intereye difference in axial length at the last follow-up (P = 0.047, 95%CI 0.005–0.627).

Conclusion

Anisometropia might progress after bilateral IOL implantation in patients with pediatric cataract. Greater intereye difference in IOL power, presence of strabismus might increase the potential of progressive anisometropia.

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Fig. 1: Distributions of anisometropia.
Fig. 2: The relationship of anisometropia at two time points.

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Data availability

All data will be available from the corresponding author upon request.

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Funding

This study was supported by the National Natural Science Foundation of China (No. 81670840; No.82000874). The funding organizations had no role in the design or conduct of this research.

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Author notes

  1. These authors contributed equally: Enze liu, Lei Lin.

  2. These authors jointly supervised this work: Yun-e Zhao, Jin Li.

Authors and Affiliations

  1. National Clinical Research Center for Ocular diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China

    Enze liu, Lei Lin, Mengdi Zhang, Jiasheng Liu, Mengchao Zhu, Kaiyi Zhu, Er Mo, Jialin Xu, Yun-e Zhao & Jin Li

  2. Department of Cataract, Eye Hospital of Wenzhou Medical University, 618#Fengqi East Road, Hangzhou, Zhejiang, China

    Er Mo & Yun-e Zhao

Authors
  1. Enze liu
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Contributions

El and LL was responsible for conceptualization, methodology, investigation, analysis and interpretation of data, writing–original draft preparation, writing–reviewing and editing. MZ was responsible for investigation, critical revision of the academic content of the manuscript. JL and MZ was responsible for methodology. KZ contributed to investigation. EM and JX contributed to formal analysis. Y-eZ and JL was responsible for conceptualization, writing–reviewing and editing, funding support.

Corresponding authors

Correspondence to Yun-e Zhao or Jin Li.

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liu, E., Lin, L., Zhang, M. et al. Factors associated with progressive anisometropia after bilateral intraocular lens implantation in patients with pediatric cataract. Eye 38, 594–599 (2024). https://doi.org/10.1038/s41433-023-02740-4

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