Abstract
Background
Myostatin functions as a negative regulator of skeletal muscle growth. The association of myostatin with muscle parameters in dialysis patients is inconsistent, and there are no studies associating myostatin with physical function and outcomes in peritoneal dialysis (PD) patients. Therefore, we assessed the association of serum myostatin with lean mass, physical function, and hospitalization in a prospective cohort of PD patients.
Methods
Lean mass, physical function, and serum myostatin were assessed at baseline. Patients were followed up for at least 24 months and hospitalization was recorded.
Results
Serum myostatin levels were positively correlated with handgrip strength and Appendicular Lean Mass Index among male patients. Binary logistic regression models were performed including myostatin levels and physical function parameters as independent variables. Serum myostatin, handgrip strength, gait speed, and Short Physical Performance Battery were associated with hospitalization.
Conclusion
Lower serum myostatin and physical function were associated with hospitalization in PD patients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Data availability
All data generated or analyzed during this study are included in this published article.
References
McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997;387:83–90. https://doi.org/10.1038/387083a0
Baczek J, Silkiewicz M, Wojszel ZB. Myostatin as a biomarker of muscle wasting and other pathologies-state of the art and knowledge gaps. Nutrients. 2020;12:2401. https://doi.org/10.3390/nu12082401
Bataille S, Chauveau P, Fouque D, Aparicio M, Koppe L. Myostatin and muscle atrophy during chronic kidney disease. Nephrol Dial Transplant. 2020:gfaa129. https://doi.org/10.1093/ndt/gfaa129.
Delanaye P, Bataille S, Quinonez K, Buckinx F, Warling X, Krzesinski JM, et al. Myostatin and insulin-like growth factor 1 are biomarkers of muscle strength, muscle mass, and mortality in patients on hemodialysis. J Ren Nutr. 2019;29:511–20. https://doi.org/10.1053/j.jrn.2018.11.010
Lee SM, Kim SE, Lee JY, Jeong HJ, Son YK, An WS. Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients. Kidney Res Clin Pract. 2019;38:481–9. https://doi.org/10.23876/j.krcp.19.019
Yamada S, Tsuruya K, Yoshida H, Tokumoto M, Ueki K, Ooboshi H, et al. Factors associated with the serum myostatin level in patients undergoing peritoneal dialysis: potential effects of skeletal muscle mass and vitamin Dreceptor activator use. Calcif Tissue Int. 2016;99:13–22. https://doi.org/10.1007/s00223-016-0118-6
Silva MZC, Vogt BP, Reis NSC, Caramori JCT. Update of the European consensus on sarcopenia: what has changed in diagnosis and prevalence in peritoneal dialysis? Eur J Clin Nutr. 2019;73:1209–11. https://doi.org/10.1038/s41430-019-0468-z
Bergen HR, Farr JN, Vanderboom PM, Atkinson EJ, White TA, Singh RJ, et al. Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay. Skelet. Muscle. 2015;15:21. https://doi.org/10.1186/s13395-015-0047-5.
Zhou Y, Hellberg M, Hellmark T, Hoglund P, Clyne N. Muscle mass and plasma myostatin after exercise training: a substudy of Renal Exercise (RENEXC)—a randomized, controlled trial. Nephrol Dial Transpl. 2021;36:95–103. https://doi.org/10.1093/ndt/gfz210
Author information
Authors and Affiliations
Contributions
MZCS, BPV, and MFM were responsible for conceptualization and methodology; MZCS, NSCR, FCM, and MSD performed data acquisition; MZCS, BPV, and MFM performed data analysis and interpretation, were involved in formal analysis and wrote the original draft; MZCS, BPV, NSCR, FCM, MSD, MFM, and JCTC revised and edited the manuscript; JCTC, MFM, and BPV were responsible for supervision and mentorship. All authors provided intellectual content of critical importance to the work and gave final approval for the version to be published.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Silva, M.Z.C., Vogt, B.P., Reis, N.S.C. et al. Serum myostatin levels are associated with physical function and hospitalization in peritoneal dialysis patients. Eur J Clin Nutr 77, 292–294 (2023). https://doi.org/10.1038/s41430-022-01227-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41430-022-01227-x