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The effect of a high-selenium lentil diet on cardiovascular risk markers in an arsenic-exposed population


Chronic arsenic exposure is associated with a number of systemic diseases, including cardiovascular disease. Selenium has been shown to promote arsenic excretion from the body. We investigated if a high-selenium lentil diet has an effect on blood pressure and plasma lipid levels in an arsenic-exposed population by conducting a 6-month randomized controlled dietary intervention trial with 405 participants.

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Fig. 1: Within group differences in cholesterol levels in the low- and high-Se groups throughout the intervention trial.


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The authors conceived (JS) and contributed to study design and implementation (RK, EA, RR, JS) laboratory analyses (RK, EA), interpretation of results and writing of the manuscript (RK, EA, RR, JS). GK performed statistical analyses and aided in drafting the manuscript.

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Correspondence to Regina M. Krohn.

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The authors declare no competing interests.

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Krohn, R.M., Akhtar, E., Kwong, G.P.S. et al. The effect of a high-selenium lentil diet on cardiovascular risk markers in an arsenic-exposed population. Eur J Clin Nutr (2021).

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