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COVID-19 pandemic: the effects of quarantine on cardiovascular risk


COVID-19 is causing a global pandemic with a high number of deaths and infected people. To contain the diffusion of COVID-19 virus, Governments have enforced restrictions on outdoor activities or even collective quarantine on the population. One important consequence of quarantine is a change in lifestyle: reduced physical activity and unhealthy diet. 2019 guidelines for primary prevention of cardiovascular disease indicate that “Adults should engage in at least 150 minute per week of accumulated moderate-intensity or 75 minute per week of vigorous-intensity aerobic physical activity (or an equivalent combination of moderate and vigorous activity) to reduce ASCVD risk.” During quarantine, strategies to further increase home-based physical activity and to follow a healthy diet should be implemented. Quarantine carries some long-term effects on cardiovascular disease, mainly related to unhealthy lifestyle and anxiety. Following quarantine a global action supporting healthy diet and physical activity is mandatory to encourage people to return to good lifestyle.


Quarantine and isolation are two measures that can prevent, or at least minimize, the impact of infectious disease outbreaks. In public health practice, “quarantine” refers to the separation of persons (or communities) who have been exposed to an infectious disease. “Isolation,” in contrast, applies to the separation of persons who are known to be infected [1]. There are several examples of Government imposed quarantine or travel bans, i.e., at least 18 US states quarantined people returning from West Africa during the 2014 Ebola outbreak [1]. Now, COVID-19 infection is causing a global pandemic with a high number of deaths. By March 29, Italy reported 10,023 deaths (Italian Health Ministry, [2]. To contain the diffusion of the COVID-19 virus, the Italian Government as well as others have enforced on the population. The previous experience of the SARS outbreak showed the efficacy of timely quarantine and isolation measures [3, 4]. Quarantine is often an unpleasant experience: loss of freedom, uncertainty over disease status, and boredom can create dramatic effects. The potential benefits of mandatory mass quarantine need to be weighed carefully against the possible long-term negative effects on cardiovascular risk burden [4, 5].

Quarantine and diet

The main consequence of quarantine is a change in lifestyle and nutritional habits (Table 1). Nutritional habits will change due to reduced availability of goods, limited access to food caused by restricted store opening hours, and to a switch to unhealthy food. A recent review on the psychological impact of quarantine [6] reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. Having inadequate basic supplies (e.g., food, water) during quarantine was a source of frustration [7] and continued to be associated with anxiety and anger for 4–6 months following release [7, 8]. Due to anxiety of future food shortage, it is plausible that people will purchase packaged and long-life food rather than fresh food. This leads to weight gain and to a reduced intake of antioxidants. Oxidative stress and mild chronic vascular inflammation are part of the pathophysiology of hypertension and atherosclerosis [9]. Diets rich in antioxidant food (i.e., Mediterranean diet and Dash diet) are vascular protective. Several studies found that the Mediterranean diet is associated with a reduction in incidence, prevalence, and mortality from coronary artery disease, cardiovascular disease, diabetes, and in all-causes mortality including cancer [10, 11]. A systematic review on 7186 subjects (5168 subjects assigned to a Mediterranean diet), reported a significant reduction in central obesity with a Mediterranean-type diet [12]. Mediterranean diet is naturally low in sodium due to its low degree of processing, unlike processed foods (a term that covers all foods that have undergone manufacturing methods, including convenience foods and products like bread, cheese, and meat products) and is also rich in fruit and vegetables [13]. Diets rich in fruits and vegetables have several positive effects: known health benefits of high flavonol intake, potential increase in nitric oxide species, concomitant weight loss, reduction of blood pressure, and reduction of inflammatory markers [14, 15]. These beneficial effects are similar in men and women despite the fact that adherence to diet and healthy lifestyle is influenced by gender [11, 16].

Table 1 What is known about quarantine and isolation.

Quarantine induces anxiety and stress. Torres and Nowson analyzed the relationship between stress and eating behavior and identified that people cope with stress by eating and drinking in an attempt to feel better (“stress-related eating”). These stress-driven eaters and drinkers were more likely to eat unhealthy foods such as snacks, hamburgers, soda cola, and chocolate regularly and to drink wine and spirits more frequently. In addition, the lack of emotional support from friends and relatives was predictive of stress-driven eating and drinking behaviors [17, 18]. During quarantine, stress-driven eaters would easily switch from a healthy diet to unhealthy ones. This would affect cardiovascular risk mainly in high-risk patients.

Quarantine and physical activity

Together with the unhealthy diet, the reduction of physical activity will contribute to weight gain during quarantine. Regular physical activity is mandatory to maintain health status, and is associated with reduction in cardiovascular risk [11, 19]. The OMS suggests performing physical activity, such as walking, cycling, sports, dance, and yoga, in a manner that will prevent noncommunicable disease [20]. During quarantine the Italian Government prohibited the great majority of outdoor and social activities (e.g., going to the gym) resulting in a reduction of physical activity. Despite the guidelines to workout at home, only few subjects comply.

The reduction of physical activity will increase oxidative stress. Oxidative stress leads to apoptotic cell death of endothelial cells, reduces nitric oxide levels, increases activity of matrix metalloproteases and amplifies vascular inflammation, provoking vasoconstriction, LDL oxidation, and accumulation of foam cells [19, 21]. Oxidative stress is mutually linked to inflammation, often associated with an increased risk of endothelial dysfunction [21]. In addition, obesity is associated with elevated circulating levels of IL-6 and TNFα, which are subsequently decreased with weight loss. In obese subjects, adipose tissue becomes dysfunctional, promoting a pro-inflammatory, hyperlipidemic, and insulin resistant environment that contributes to cardiovascular disease [22].

It is well recognized that chronic physical activity attenuates oxidative stress in healthy subjects via the improvement of antioxidant enzyme capacities and inflammation via the enhancement of anti-inflammatory molecules [23]. The reduction of physical activity worsens cardiovascular risk by increasing cardiovascular risk factors burden.

Quarantine and well-being

The role of negative psychological factors—including depression, anxiety, and hostility—in the development and progression of cardiovascular disease is well established [24, 25].

By contrast, several studies have linked positive psychological characteristics with lower levels of traditional cardiovascular risk factors and decreased incidence of CV disease [26]. Prospective investigations of patients with existing CVD have shown that greater positive well-being is associated with reduced risk of secondary cardiovascular events and mortality [26, 27].

Positive well-being is thought to influence cardiovascular disease by (a) promoting adaptive physiological functioning, (b) motivating better health behaviors, and (c) buffering against the detrimental effects of stress on health [26, 28, 29]. These three pathways are interrelated and not mutually exclusive.

Positive well-being may act as a modifiable protective factor that could reduce the burden of CVD through its potential influences on lifestyle behaviors [24, 26,27,28]. People with higher positive well-being tend to have better health behaviors, including nonsmoking, greater physical activity, better dietary patterns, and lower incidence of sleep disturbances. It remains unclear whether positive well-being leads to better subsequent health behaviors or vice versa, however a strong relationship has been demonstrated. Positive well-being is thought to have multiple salutary effects during stress, such as reducing inflammatory and cardiovascular responses to acute stressors. Positive well-being also acts on cardiovascular function and cardiac autonomic control, reducing heart rate and blood pressure [24, 26].

Effects of quarantine in the long-term period

It is difficult to see the acute effects of quarantine on atherosclerosis. Nonhealthy lifestyle through increase of inflammatory status could trigger activation of preexisting plaques. We cannot exclude that changes in lifestyle persist after quarantine. In this case the risk of an economic crisis will maintain stress and anxiety in subjects, principally in those belonging to low socio-economic categories, leading to an increase in cardiovascular risk.

Following the Spagnola pandemic throughout 1918, a peak of cardiovascular events was reported. Such events manifest from 7 to 10 days after the emergence of influenza symptoms. In 1918, immediately after the end of the Spagnola epidemic, deaths caused by cardiovascular events had outmatched deaths from other causes, including superimposed pneumonia [30, 31].

What must be done to prevent increase of obesity and of cardiovascular risk

We think cardiologists need to be prepared to face the likely increase in obesity immediately after the end of the pandemic.

During quarantine we must promote physical activity at home. Little information is available on effects of home-based physical activity on chronic disease [32,33,34]. Despite physical activity being defined mandatory for cardiovascular prevention, guidelines do not contain home-based physical activity indications [35]. The “2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease” recommended that “Adults should engage in at least 150 minute per week of accumulated moderate-intensity or 75 minute per week of vigorous-intensity aerobic physical activity (or an equivalent combination of moderate and vigorous activity) to reduce ASCVD risk” (Class I LOE B-NR) or “for adults unable to meet the minimum physical activity recommendations, engaging in some moderate- or vigorous-intensity physical activity, even if less than this recommended amount, can be beneficial to reduce ASCVD risk” (Class IIa LOE B-NR) [35].

The WHO has just released guidance to “Stay physically active during self-quarantine” in order to improve healthy behaviour during quarantin [36]. Today there are thousands of workout videos available on the Internet. The goal is to assist people perform these workouts independently on their own. A common observation is that even people who visit gym regularly find it difficult to perform all steps (body pose alignments) in a workout accurately. By continuously doing an exercise incorrectly may eventually cause severe long-term injuries [37].

After quarantine we need to reevaluate the cardiovascular risk in patients together with metabolic parameters including glycemic status. Patients also need to be evaluated by psychologist to early identify the persistence of anxiety and stress (Table 2). A global action supporting healthy diet and physical activity is mandatory to encourage people to return to good lifestyle. This action has to be stronger at a low socio-economic level where individuals will suffer to a higher degree from the restrictions.

Table 2 Key point for managing patients after pandemic COVID-19 restriction.


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We would like to thank Mrs Janet Ann Carter for reviewing the paper. We thank everyone who is working to resolve the SARS-Cov-2 pandemic.

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MBP, MN, and AVM conceived of the idea at the basis of the article. AVM, MN, and MBP developed the different parts of the manuscript. All authors performed the final supervision. All authors contributed to and approved the final manuscript.

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Correspondence to Anna Vittoria Mattioli.

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Mattioli, A.V., Ballerini Puviani, M., Nasi, M. et al. COVID-19 pandemic: the effects of quarantine on cardiovascular risk. Eur J Clin Nutr 74, 852–855 (2020).

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