Clinical nutrition

A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular adhesion molecules in type 2 diabetes mellitus

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Soluble forms of vascular adhesion molecules, ICAM-1 and VCAM-1, accelerate atherosclerosis pathogenesis. The present study was conducted to evaluate the effect of daily supplementation of 3 g cinnamon on the plasma levels of ICAM-1 and VCAM-1 among patients with type 2 diabetes. This randomized double-blind placebo-controlled trial was performed on 44 adult patients with type 2 diabetes aged 25–70 years. The patients were randomized to two groups of intervention (n = 22) and control (n = 22), differing by daily cinnamon supplementation or placebo (3 g) for 8 weeks. Plasma levels of ICAM-1 and VCAM-1 were measured at the beginning and end of the study. After 8 weeks, 39 subjects (n = 20 in the cinnamon and n = 19 in the placebo groups) completed the trial. There was a significant reduction in the mean levels of ICAM-1 and VCAM-1 within cinnamon and placebo groups (P < 0.001). But there was no significant difference in ICAM-1 (P = 0.75) and VCAM-1 (P = 0.72) between the groups at the end of the trial. According to the results, cinnamon supplementation has no beneficial effect on the reduction of ICAM-1 and VCAM-1 levels in patients with type 2 diabetes, which have a role in the development of atherogenesis.

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The dataset supporting the findings of this article is available upon request from the corresponding author.


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The authors would like to gratitude the Research Institute for Endocrine Science, Shahid Beheshti University of Medical Science, Tehran, Iran, for financial support of this study. And special thanks to the participants for their cooperation.

Author information

BT, PM, and MH have designed and supervised the project, BT, SS. RT, and SB have contributed in data collection, conception, and statistical analysis. BT and MD have written the first draft of the paper. RH completed the revised paper and drew the figures by graph pad prism. All authors have done their duty under the supervision of PM as the main author. Also, all authors approved the final version of the paper.

Correspondence to Behrouz Talaei.

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Mirmiran, P., Davari, M., Hashemi, R. et al. A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular adhesion molecules in type 2 diabetes mellitus. Eur J Clin Nutr (2019) doi:10.1038/s41430-019-0523-9

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