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The association of lecithin retinol acyltransferase and the 25(OH)D receptor with pediatric overweight and obesity

European Journal of Clinical Nutrition volume 73, pages 1626–1629 (2019)Cite this article

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Abstract

The aim of this study is to determine whether lecithin retinol acyltransferase (LRAT) as well as biomarkers of vitamin A (VA) and vitamin D are related to indices of obesity in childhood. A total of 164 children (aged 6–12 years, female 49.39%), comprising 66 children in the overweight/obese group and 98 children in the lean group, were included. LRAT expression was remarkably lower in the overweight/obese group than in the lean group (P < 0.01). Compared with the lean group, the overweight/obese group had elevated VA (0.95 ± 0.25 vs. 0.83 ± 0.21 µmol/L, P < 0.01). Moreover, the levels of 25(OH)D (25-hydroxyvitamin D) and its receptor were lower in overweight/obese subjects than in lean subjects (P = 0.06 and <0.05). LRAT was negatively correlated with body mass index and waist circumference (R = −0.27, P < 0.01, and R = −0.18, P < 0.05, respectively) and positively correlated with high-density lipoprotein (R = 0.18, P < 0.05). VA metabolism may be disordered in obese children, although children with obesity have higher VA levels than lean children.

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Requests for access to detail data should be made to XH Liang (Email: xiaohualiang@hospital.cqmu.edu.cn).

References

  1. Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, et al. Trends in obesity prevalence among children and adolescents in the United States, 1988–1994 through 2013–2014. JAMA. 2016;315:2292–9. https://doi.org/10.1001/jama.2016.6361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zhou Y, Zhang Q, Wang T, Zhang Y, Xu B. Prevalence of overweight and obesity in Chinese children and adolescents from 2015. Ann Hum Biol. 2017;44:642–3. https://doi.org/10.1080/03014460.2017.1371224

    Article  PubMed  Google Scholar 

  3. Li X, Li S, Ulusoy E, Chen W, Srinivasan SR, Berenson GS. Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation. 2004;110:3488–92. https://doi.org/10.1161/01.cir.0000149713.48317.27.

    Article  PubMed  Google Scholar 

  4. Hui YY-k FAN, Updating MJ. blood pressure references for Chinese children aged 3–17 years. Chin J Hypertens. 2017;05:8.

    Google Scholar 

  5. Blomhoff R, Green MH, Berg T, Norum KR. Transport and storage of vitamin A. Science. 1990;250:399–404.

    Article  CAS  Google Scholar 

  6. Noy N. Vitamin A in regulation of insulin responsiveness: mini review. Proc Nutr Soc. 2016;75:212–5. https://doi.org/10.1017/S0029665115004322

    Article  CAS  PubMed  Google Scholar 

  7. Trasino SE, Tang XH, Jessurun J, Gudas LJ. Obesity leads to tissue, but not serum vitamin A deficiency. Sci Rep. 2015;5:15893 https://doi.org/10.1038/srep15893.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Takitani K, Miyazaki H, Fukunishi S, Takaya R, Yoden A, Higuchi K, et al. Altered expression of both beta-carotene 15,15’ monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats. J Nutr Sci Vitaminol (Tokyo). 2011;57:108–13.

    Article  CAS  Google Scholar 

  9. Plesner JL, Dahl M, Fonvig CE, Nielsen TRH, Kloppenborg JT, Pedersen O, et al. Obesity is associated with vitamin D deficiency in Danish children and adolescents. J Pediatr Endocrinol Metab. 2018;31:53–61. https://doi.org/10.1515/jpem-2017-0246

    Article  CAS  PubMed  Google Scholar 

  10. Gil A, Plaza-Diaz J, Mesa MD. Vitamin D: classic and novel actions. Ann Nutr Metab. 2018;72:87–95. https://doi.org/10.1159/000486536.

    Article  CAS  PubMed  Google Scholar 

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Funding

This study was supported by National Natural Science Foundation of China (81502826) and China Postdoctoral Science Foundation (2014M562289).

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  1. These authors contributed equally: Xiaohua Liang, Yun He

Authors and Affiliations

  1. Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Paediatrics in Chongqing, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing, China

    Xiaohua Liang, Yun He, Min Chen, Qu Ping & Jie Chen

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  1. Xiaohua Liang
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  2. Yun He
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  4. Qu Ping
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Correspondence to Xiaohua Liang.

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Liang, X., He, Y., Chen, M. et al. The association of lecithin retinol acyltransferase and the 25(OH)D receptor with pediatric overweight and obesity. Eur J Clin Nutr 73, 1626–1629 (2019). https://doi.org/10.1038/s41430-019-0422-0

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