Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn’s disease

European Journal of Clinical Nutrition volume 72, pages1183–1186(2018)Cite this article

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Abstract

In order to identify the factors that could predict the efficacy of exclusive enteral nutrition (EEN) in inducing remission of active CD. Baseline clinical and laboratory covariates were correlated with the outcome (clinical remission) of EEN in active CD (CDAI ≥150) by both univariable and multivariable analyses. A total of 67 from a consecutive of 136 active CD patients were enrolled. L4b (from treitz ligament to distal 1/3 ileum) involvement was negatively and high serum albumin (≥35 g/L) was positively associated with clinical remission (OR: 0.14, OR: 14.71). In conclusion, L4b sparing and high serum albumin might predict a favorable outcome of EEN in active CD (ClinicalTrials.gov ID: NCT 02942511).

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Acknowledgements

This work was supported by the Natural Science Foundation of Zhejiang Province (LQ17H160010), Zhejiang Provincial Medical and Health Research Project (2015104960), and National Natural Science Foundation of China (81702308, 81700455).

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    1. Center for Inflammatory Bowel Diseases, Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

      Meng Xue, Hanyun Zhang, Xiaoying Wang, Dingting Xu, Dan Jin, Peiwei Li, Jun Ye, Qiao Yu & Yan Chen

    2. Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China

      Meng Xue

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    1. Meng Xue
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    2. Hanyun Zhang
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    3. Xiaoying Wang
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    9. Yan Chen
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    Correspondence to Yan Chen.

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    These two authors contributed equally: Meng Xue, Hanyun Zhang.

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    Xue, M., Zhang, H., Wang, X. et al. Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn’s disease. Eur J Clin Nutr 72, 1183–1186 (2018). https://doi.org/10.1038/s41430-018-0198-7

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