Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn’s disease


In order to identify the factors that could predict the efficacy of exclusive enteral nutrition (EEN) in inducing remission of active CD. Baseline clinical and laboratory covariates were correlated with the outcome (clinical remission) of EEN in active CD (CDAI ≥150) by both univariable and multivariable analyses. A total of 67 from a consecutive of 136 active CD patients were enrolled. L4b (from treitz ligament to distal 1/3 ileum) involvement was negatively and high serum albumin (≥35 g/L) was positively associated with clinical remission (OR: 0.14, OR: 14.71). In conclusion, L4b sparing and high serum albumin might predict a favorable outcome of EEN in active CD (ClinicalTrials.gov ID: NCT 02942511).

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This work was supported by the Natural Science Foundation of Zhejiang Province (LQ17H160010), Zhejiang Provincial Medical and Health Research Project (2015104960), and National Natural Science Foundation of China (81702308, 81700455).

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Correspondence to Yan Chen.

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The authors declare that they have no conflict of interest.

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These two authors contributed equally: Meng Xue, Hanyun Zhang.

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Xue, M., Zhang, H., Wang, X. et al. Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn’s disease. Eur J Clin Nutr 72, 1183–1186 (2018). https://doi.org/10.1038/s41430-018-0198-7

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