Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn’s disease

Abstract

In order to identify the factors that could predict the efficacy of exclusive enteral nutrition (EEN) in inducing remission of active CD. Baseline clinical and laboratory covariates were correlated with the outcome (clinical remission) of EEN in active CD (CDAI ≥150) by both univariable and multivariable analyses. A total of 67 from a consecutive of 136 active CD patients were enrolled. L4b (from treitz ligament to distal 1/3 ileum) involvement was negatively and high serum albumin (≥35 g/L) was positively associated with clinical remission (OR: 0.14, OR: 14.71). In conclusion, L4b sparing and high serum albumin might predict a favorable outcome of EEN in active CD (ClinicalTrials.gov ID: NCT 02942511).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1
Fig. 2

References

  1. 1.

    Gomollón F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO, et al. 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and medical management. J Crohns Colitis. 2017;11:3–25.

    Article  Google Scholar 

  2. 2.

    Lau C, Dubinsky M, Melmed G, Vasiliauskas E, Berel D, McGovern D, et al. The impact of preoperative serum anti-TNFα therapy levels on early postoperative outcomes in inflammatory bowel disease surgery. Ann Surg. 2015;261:487–96.

    Article  Google Scholar 

  3. 3.

    Baumgart DC, Sandborn WJ. Crohn’s disease. Lancet. 2012;380:1590–605.

    Article  Google Scholar 

  4. 4.

    Borrelli O, Cordischi L, Cirulli M, Paganelli M, Labalestra V, Uccini S, et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clin Gastroenterol Hepatol. 2006;4:744–53.

    Article  Google Scholar 

  5. 5.

    Wall CL, Day AS, Gearry RB. Use of exclusive enteral nutrition in adults with Crohn’s disease: a review. World J Gastroenterol. 2013;19:7652–60.

    Article  Google Scholar 

  6. 6.

    Hyams JS. Standardized recording of parameters related to the natural history of inflammatory bowel disease: from Montreal to Paris. Dig Dis. 2014;32:337–44.

    Article  Google Scholar 

  7. 7.

    Wilschanski M, Sherman P, Pencharz P, Davis L, Corey M, Griffiths A. Supplementary enteral nutrition maintains remission in paediatric Crohn’s disease. Gut. 1996;38:543–8.

    CAS  Article  Google Scholar 

  8. 8.

    Guo Z,Zhu W,Gong J,Zhang W,Wang Z,Li N, et al. Effects of exclusive enteral nutrition on the mucosal healing in adult patients with active Crohn’s Disease. Chin J Dig Dis. 2013;33:831–4.

    Google Scholar 

  9. 9.

    Ruuska T, Savilahti E, Mäki M, Ormälä T, Visakorpi JK. Exclusive whole protein enteral diet versus prednisolone in the treatment of acute Crohn’s disease in children. J Pediatr Gastroenterol Nutr. 1994;19:175–80.

    CAS  Article  Google Scholar 

  10. 10.

    Datta G, Gnanalingham KK, van Dellen J, O’Neill K. The role of parenteral nutrition as a supplement to enteral nutrition in patients with severe brain injury. Br J Neurosurg. 2003;17:432–6.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the Natural Science Foundation of Zhejiang Province (LQ17H160010), Zhejiang Provincial Medical and Health Research Project (2015104960), and National Natural Science Foundation of China (81702308, 81700455).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Yan Chen.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

These two authors contributed equally: Meng Xue, Hanyun Zhang.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Xue, M., Zhang, H., Wang, X. et al. Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn’s disease. Eur J Clin Nutr 72, 1183–1186 (2018). https://doi.org/10.1038/s41430-018-0198-7

Download citation

Further reading

Search

Quick links