To assess the association between processed meat and the risk of selected digestive tract and laryngeal cancers.
We conducted a series of case-control studies between 1985 and 2007 in Italy. The studies included a total of 1475 cases of cancer of the oral cavity and pharynx, 1077 of the larynx, 716 of the esophagus, 999 of the stomach, 684 of the liver, 159 of the biliary tract, 688 of the pancreas, and a total of 9720 controls. Odds ratios (ORs), and the corresponding 95% confidence intervals (CIs), were estimated by unconditional logistic regression models, including terms for socio-demographic factors, tobacco smoking, and alcohol intake.
Compared to the lowest tertile of processed meat consumption, the ORs for subjects in the highest one were 1.18 (95% CI 0.98–1.43) for oral cavity and pharyngeal, 1.51 (95% CI 1.18–1.91) for esophageal, 1.19 (95% CI 0.96–1.47) for laryngeal, 0.98 (95% CI 0.81–1.18) for stomach, 0.85 (95% CI 0.51–1.40) for biliary tract, 1.20 (95% CI 0.94–1.54) for liver, and 1.46 (95% CI 1.15–1.85) for pancreatic cancers.
Our findings support the hypothesis that high processed meat consumption increases esophageal and pancreatic cancers risk. Residual confounding by socio-demographic factors, tobacco smoking, and alcohol intake may, partly or largely, account for these associations. We found no overall association with other digestive tract and laryngeal cancers.
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This work was conducted within a grant by the Italian Foundation for Cancer Research (FIRC) and received unconditional support by ASSICA. Funders had no role in study design, data collection, analysis or interpretation, manuscript preparation, or the decision to publish. VR was supported by a fellowship from the Italian Foundation for Cancer Research (FIRC No. 18107). In addition, DK was supported by JSPS Grant-in-Aid for Young Scientists (B) (No. 15K21283).
Conflict of interest
Partially supported by unconditional grant to the Department of Clinical Sciences and Community Health, University of Milan, by ASSICA.
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Rosato, V., Kawakita, D., Negri, E. et al. Processed meat and risk of selected digestive tract and laryngeal cancers. Eur J Clin Nutr 73, 141–149 (2019). https://doi.org/10.1038/s41430-018-0153-7
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