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Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

European Journal of Clinical Nutrition volume 72, pages 460–463 (2018)Cite this article

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Abstract

Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7–18 wk) and second (20–27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of ≥30 kg/m2, a history of GDM, or both. The participants were stratified by first-trimester BMI: BMI of <25.0, 25.0–29.9, 30.0–34.9, and ≥35 kg/m2. In the BMI group ≥35 kg/m2, those who did not develop GDM during the follow-up showed higher increase in serum 25(OH)D concentrations compared with women who developed GDM (43.2 vs. 11.5%; P < 0.001). No associations between 25(OH)D concentrations and GDM were observed in other BMI groups. These findings give an important aspect of the role of maternal body size in the association between vitamin D and GDM in high-risk women.

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Funding

The RADIEL study was supported by the funding from Jalmari and Rauha Ahokas Foundation (JGE), Finnish Foundation for Cardiovascular Disease (JGE), Special state subsidy for health science research of Helsinki University Central Hospital (JGE), Samfundet Folkhälsan (JGE), The Finnish Diabetes Research Foundation (JGE), State Provincial Office of Southern Finland (JGE), the Social Insurance Institution of Finland, and the Academy of Finland (JGE) (grant no. 129369, 129907, 135072, 129255, and 126775). The research leading to these results has received funding from the European Commission within the 7th Framework Programme (DORIAN, grant agreement no. 278603) and EU H2020-PHC-2014-DynaHealth (grant no. 633595). None of the funders had role in the design, analysis or writing of this article.

Author contributions

AV, JM, SK, JL, KR, AT, BS-L, HK, HV, SA, JGE: designed and conducted the study; AV, HK: analyzed the data; HV and SA: provided essential materials for research; AV: interpreted the data and wrote the first draft of the manuscript; had primary responsibility for the final content of the manuscript; and all authors: edited and contributed to the preparation of all sections of the manuscript and read and approved the final manuscript.

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Authors and Affiliations

  1. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland

    Anita J Valkama, Jelena M Meinilä, Hannu J Kautiainen & Johan G Eriksson

  2. Folkhälsan Research Center, University of Helsinki, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland

    Anita J Valkama, Heli Viljakainen & Johan G Eriksson

  3. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Sofianlehdonkatu 5A, P.O. Box 610, 00029, Helsinki, Finland

    Saila B Koivusalo, Kristiina Rönö & Aila E Tiitinen

  4. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, P.O. Box 30, 00271, Helsinki, Finland

    Jaana Lindström & Johan G Eriksson

  5. Department of Obstetrics and Gynecology, South Karelia Central Hospital, Valto Käkelän katu 3, 53130, Lappeenranta, Finland

    Beata Stach-Lempinen

  6. Department of General Practice and Primary Health Care, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, 70211, Kuopio, Finland

    Hannu J Kautiainen

  7. Children’s Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, 00029, Helsinki, Finland

    Heli Viljakainen & Sture Andersson

Authors
  1. Anita J Valkama
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  2. Jelena M Meinilä
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  3. Saila B Koivusalo
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  4. Jaana Lindström
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  5. Kristiina Rönö
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  6. Aila E Tiitinen
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  7. Beata Stach-Lempinen
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  8. Hannu J Kautiainen
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  9. Heli Viljakainen
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  10. Sture Andersson
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  11. Johan G Eriksson
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Corresponding author

Correspondence to Anita J Valkama.

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The authors declare that they have no competing interests.

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Valkama, A.J., Meinilä, J.M., Koivusalo, S.B. et al. Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women. Eur J Clin Nutr 72, 460–463 (2018). https://doi.org/10.1038/s41430-017-0010-0

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  • DOI: https://doi.org/10.1038/s41430-017-0010-0

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