Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

The Journal of Antibiotics (2024)Cite this article

Subjects

Abstract

A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Barka EA, Vatsa P, Sanchez L, Gaveau-Vaillant N, Jacquard C, Klenk HP, et al. Taxonomy, Physiology, and Natural Products of Actinobacteria. Microbiol Mol Biol Rev. 2015;80:1–43.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Subramani R, Aalbersberg W. Culturable rare Actinomycetes: diversity, isolation and marine natural product discovery. Appl Microbiol Biotechnol. 2013;97:9291–321.

    Article  CAS  PubMed  Google Scholar 

  3. Nakashima T, Takahashi Y, Ōmura S. Search for new compounds from Kitasato microbial library by physicochemical screening. Biochem Pharm. 2017;134:42–55.

    Article  CAS  PubMed  Google Scholar 

  4. Nakashima T, Okuyama R, Kamiya Y, Matsumoto A, Iwatsuki M, Inahashi Y, et al. Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510. J Antibiot. 2013;66:311–7.

    Article  CAS  Google Scholar 

  5. Inahashi Y, Iwatsuki M, Ishiyama A, Matsumoto A, Hirose T, Oshita J, et al. Actinoallolides A–E, New Anti-trypanosomal Macrolides, Produced by an Endophytic Actinomycete, Actinoallomurus fulvus MK10-036. Org Lett. 2015;17:864–7.

    Article  CAS  PubMed  Google Scholar 

  6. Awano Y, Tsutsumi H, Kikuchi Y, Kimishima A, Iwatsuki M, Asami Y, et al. Emblestatin: a new peptide antibiotic from Embleya scabrispora K20-0267. J Antibiot. 2023;76:592–7.

    Article  CAS  Google Scholar 

  7. Itoh A, Ido J, Iwamoto Y, Goshima E, Miki T, Hasuda K, et al. YS-822A, a new polyene macrolide antibiotic. I. Production, isolation, characterization and biological properties. J Antibiot. 1990;43:948–55.

    Article  CAS  Google Scholar 

  8. Hirota H, Itoh A, Ido J, Iwamoto Y, Goshima E, Miki T, et al. YS-822A, a new polyene macrolide antibiotic. II. Planar structure of YS-822A. J Antibiot. 1991;44:181–6.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are grateful to Distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support and valuable suggestions and to Dr. K. Nagai, Ms. R. Seki, and Ms. N. Sato, School of Pharmacy, Kitasato University, for the analysis of mass and NMR spectra. We thank Prof. S. Croft and Dr. V. Yardley at London School of Hygiene & Tropical Medicine (LSHTM) for their kind supports and providing us L. major MHOM/SA/62/JISH118 strain. We also thank DNDi for supports for antileishmanial screening. This study was partially supported by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grant Number 19H05685) and the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research & Development (AMED) under Grant Numbers JP19am0101096 (Phase I) and JP22ama121035 (Phase II). This study was partially supported by JSPS KAKENHI (Grant Numbers JP21K06617 and JP23H04884).

Author information

Authors and Affiliations

  1. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Yuta Awano, Yume Takahashi, Hayama Tsutsumi, Yoshihiro Watanabe, Masaaki Sonoda, Rei Hokari, Masato Iwatsuki & Yuki Inahashi

  2. School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan

    Ryoya Ishii

  3. Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Hayama Tsutsumi, Yoshihiro Watanabe, Rei Hokari, Masato Iwatsuki & Yuki Inahashi

Authors
  1. Yuta Awano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ryoya Ishii
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yume Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hayama Tsutsumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshihiro Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masaaki Sonoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rei Hokari
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masato Iwatsuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yuki Inahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuki Inahashi.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Awano, Y., Ishii, R., Takahashi, Y. et al. A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017. J Antibiot (2024). https://doi.org/10.1038/s41429-024-00737-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41429-024-00737-z

Search

Advanced search

Quick links