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Benzothioate Glycoside from a terrestrial Streptomyces sp. TBRC 11511 from Thailand

The Journal of Antibiotics volume 75, pages 583–588 (2022)Cite this article

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Abstract

A new benzothioate glycoside metabolite, phitsanoside A, together with its new and known derivatives were isolated from Streptomyces sp. TBRC 11511 collected from sediment of a dry evergreen forest located in Phitsanulok Province, Thailand. The structure elucidation of the new compound was interpreted on the basis of spectroscopic data analysis. The configuration of the sugar moiety was derived based on NOESY nuclear magnetic resonance correlations, a vicinal coupling constant analysis, and the measurement of an optical rotation from the hydrolyzed sugar unit, which was identified as β-D-glucopyranose. Phitsanoside A did not exhibit antibacterial activity against Bacillus cereus, Mycobacterium tuberculosis or Staphylococcus aureus, but phitsanoside B showed activity against all of them with MIC values of 3.13, 25 and 12.5 μg ml−1, respectively.

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Acknowledgements

We are very grateful to the National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), and a research grant from the Thailand Research Fund (TRF grant no. P17-51116) for financial support.

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Authors and Affiliations

  1. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Phahonyothin Road, Tambon Khlong Nueng, Amphoe Khlong Luang, Pathum Thani, 12120, Thailand

    Chollaratt Boonlarppradab, Siriporn Saepua, Thapanee Pruksatrakul, Wilunda Choowong, Pranee Rachtawee & Chanwit Suriyachadkun

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  1. Chollaratt Boonlarppradab
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  2. Siriporn Saepua
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  3. Thapanee Pruksatrakul
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  6. Chanwit Suriyachadkun
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Correspondence to Chollaratt Boonlarppradab.

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Boonlarppradab, C., Saepua, S., Pruksatrakul, T. et al. Benzothioate Glycoside from a terrestrial Streptomyces sp. TBRC 11511 from Thailand. J Antibiot 75, 583–588 (2022). https://doi.org/10.1038/s41429-022-00554-2

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