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Marinacarboline glucuronide, a new member of β-carboline alkaloids from sponge-derived actinomycete Actinoalloteichus cyanogriseus LHW52806

The Journal of Antibiotics volume 75, pages 523–525 (2022)Cite this article

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Abstract

A new member of β-carboline alkaloids, Marinacarboline glucuronide (1), along with nine known compounds (2–10), were isolated from static liquid fermentation extracts of Actinoalloteichus cyanogriseus LHW52806 isolated from the marine sponge Phakellia fusca. Their structures were elucidated by NMR, mass spectrometry and single-crystal X-ray diffraction. All compounds exhibited neither antimicrobial activity nor cytotoxicity. Compounds 1, 8 and 10 showed anti-inflammatory potential of significant decreasing the expressions of IL- 6 in vitro at 20 µM.

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Acknowledgements

The authors are missing Engineer Yi-zhen Yan (Ren Ji Hospital), and grateful to his sacrifices in sponge sampling and guidance on systematic isolation of natural products. This work received financial support from the National Natural Science Foundation of China (Nos. 31600014 and 22137006) and the Innovative Research Team of High-Level Local Universities in Shanghai (SHSMU-ZDCX20212702).

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Authors and Affiliations

  1. College of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, 110000, PR China

    Die Zhang & Houwen Lin

  2. Marine Drugs Research Center, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China

    Die Zhang, Jing Xu, Qi Qin, Shuping Wang, Lei Li & Houwen Lin

  3. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, PR China

    Faliang An

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Correspondence to Lei Li or Houwen Lin.

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41429_2022_552_MOESM1_ESM.docx

Marinacarboline glucuronide, a new member of β-carboline alkaloids from sponge-derived actinomycete Actinoalloteichus cyanogriseus LHW52806

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Zhang, D., Xu, J., Qin, Q. et al. Marinacarboline glucuronide, a new member of β-carboline alkaloids from sponge-derived actinomycete Actinoalloteichus cyanogriseus LHW52806. J Antibiot 75, 523–525 (2022). https://doi.org/10.1038/s41429-022-00552-4

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