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Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41

The Journal of Antibiotics volume 75, pages 509–513 (2022)Cite this article

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Abstract

The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a “heat shock metabolite” (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration.

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Acknowledgements

We thank Prof. Masaya Imoto at Juntendo University for providing actinomycete strains. This work was supported by the JSPS KAKENHI under Grant Number 20K15461 to SS.

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  1. Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan

    Shun Saito, Shiina Suzuki & Midori A. Arai

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  1. Shun Saito
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  2. Shiina Suzuki
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  3. Midori A. Arai
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Correspondence to Shun Saito or Midori A. Arai.

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Saito, S., Suzuki, S. & Arai, M.A. Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41. J Antibiot 75, 509–513 (2022). https://doi.org/10.1038/s41429-022-00551-5

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