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Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells

The Journal of Antibiotics volume 75, pages 530–533 (2022)Cite this article

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Abstract

Cell adhesion plays a crucial role in candidiasis through invasion of the human body and obtaining resistance to drugs by forming biofilms. Cell adhesion thus is a critical target for combating candidiasis by preventing the entry of fungal hyphae into the epithelium. We report here that dehydrocurvularin (1), isolated from the marine-derived fungus Curvularia aeria, exhibited anti-fungal activities for Candida albicans and Candida auris. This compound also prevented the adherence of C. albicans to human adenocarcinoma cells. Real-time RT-PCR analysis showed that exposure to 1 results in decreased expression of HWP1, EFG1, and ECE1, genes involved in Candida adhesion to epithelial cells and hyphal morphogenesis.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Number JP20K16029 to H.K.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama, 350-0295, Japan

    Hitoshi Kamauchi, Miho Furukawa, Kanako Usui, Masanori Katakura, Koichi Takao & Yoshiaki Sugita

  2. School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama, 350-0295, Japan

    Yuka Kiba & Masashi Kitamura

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  1. Hitoshi Kamauchi
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  2. Miho Furukawa
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Correspondence to Hitoshi Kamauchi.

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Kamauchi, H., Furukawa, M., Kiba, Y. et al. Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells. J Antibiot 75, 530–533 (2022). https://doi.org/10.1038/s41429-022-00543-5

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