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New antioxidants from the culture broth of Coprinopsis echinospora

The Journal of Antibiotics volume 75, pages 113–116 (2022)Cite this article

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Abstract

During the search for natural antioxidants from fungal metabolites, three new sesquiterpene derivatives (1-3) have been isolated from the culture broth of Coprinopsis echinospora. Their structures were determined by spectroscopic methods, mainly NMR and mass spectrometric analyses. These compounds exhibited antioxidant activity with IC50 values in the range of 34.4–144.5 μM in the 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging assay.

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Acknowledgements

This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1A2B2014430). Authors thank Ms. Ji-Young Oh, Center for University-wide Research Facilities (CURF) at Jeonbuk National University, for NMR measurement. This research also was supported by the “Research Base Construction Fund Support Program” funded by Jeonbuk National University in 2021.

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  1. These authors contributed equally: Dae-Won Ki, Dae-Won Kim

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  1. Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, Korea

    Dae-Won Ki, Dae-Won Kim, Ja-Gyeong Song, E-Eum Woo, Dae-Cheol Choi, In-Kyoung Lee & Bong-Sik Yun

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Correspondence to Bong-Sik Yun.

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Ki, DW., Kim, DW., Song, JG. et al. New antioxidants from the culture broth of Coprinopsis echinospora. J Antibiot 75, 113–116 (2022). https://doi.org/10.1038/s41429-021-00495-2

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