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Two new benzophenones isolated from a mangrove-derived fungus Penicillium sp.

The Journal of Antibiotics volume 74, pages 821–824 (2021)Cite this article

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Abstract

One new benzophenone derivative, named penibenzophenone C (1), and a new benzophenone natural product, neamed penibenzophenone D (2), together with two known compounds (3, 4) were isolated from the EtOAc extract of the endophytic fungus Penicillium sp. isolated from the mangrove Acanthus ilicifolius L. collected in the South China Sea. The structures of 1–4 were elucidated by extensive NMR spectral interpretation and MS data. The new compounds 1 and 2 showed moderate antibacterial activities against methicillin-resistant Staphylococcus aureus with the MIC values of 3.12 and 6.25 μg ml−1, respectively.

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Acknowledgements

This work was supported by Guangxi Young and Middle-aged University Teachers’ Scientific Research Ability Enhancement Project (2021KY0318), the Initial Scientific Research Foundation of Introduced Doctors in 2020 of Guangxi University of Chinese Medicine (2020BS024), Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (No. 2021004), the Special Fund for Bagui Scholars of Guangxi (05019055), Guangxi Province Natural Science Foundation of Innovative Research Team Project (2020GXNSFGA297002).

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  1. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, PR China

    Meng Bai, Cheng-Hai Gao, Kai Liu, Long-Yan Zhao, Zhen-Zhou Tang & Yong-Hong Liu

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  1. Meng Bai
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Correspondence to Meng Bai or Yong-Hong Liu.

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Bai, M., Gao, CH., Liu, K. et al. Two new benzophenones isolated from a mangrove-derived fungus Penicillium sp.. J Antibiot 74, 821–824 (2021). https://doi.org/10.1038/s41429-021-00464-9

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